Effect of coriaria lactone on membrane potential of hippocampal neurons in rats

Hu Mouxian; Wang Ajing; Liu Changjin; Wu Huimin; Zhu Changgeng

doi:10.1007/BF02887042

Current Medical Science ›› 2000, Vol. 20 ›› Issue (2) : 103 -105. DOI: 10.1007/BF02887042

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Effect of coriaria lactone on membrane potential of hippocampal neurons in rats

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Abstract

Intracellular recording method of electrophysiology was used to study the effect of microin jection of coriaria lactone (CL) into hippocampus on membrane potential of hippocampal neurons in rats. The membrane potential in 34 neurons of 12 rats were recorded. The results showed that CL induced depolarization of all of 34 neurons examined. Among the 34 neurons, 15 had paroxysmal depolarization accompanied by spike discharge in cluster and spike discharge in cluster ceased when membrane was hyperpolarized, 7 showed continuous depolarization accompanied by continuous spike discharge and 12 had only depolarizing response. The results suggest that injection of CL into hippocampus may lead to an increase of excitability of local neurons accompanied by different patterns of epileptioform discharge.

Keywords

coriaria lactone / hippocampus / depolarization / epilepsy

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Hu Mouxian, Wang Ajing, Liu Changjin, Wu Huimin, Zhu Changgeng. Effect of coriaria lactone on membrane potential of hippocampal neurons in rats. Current Medical Science, 2000, 20(2): 103-105 DOI:10.1007/BF02887042

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References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]

1992.1321

[2]	1996,25(6): 425

[3]	PellegrinoL J, PellegrinoA S, CushmanA J. A. Stereotaxic Atlas of the Rat Brain, 19792nd ed.WuhanPlenum Press81-81

[4]	PinanltD, LerescheN, CharpierS, et al.. Intracellular recordings in thalamic neurones during spontaneous spike and wave discharges in rats with absence epilepsy. J Physiol, 1998, 509(pt2): 449-449