Change of coagulation factor VIII and antithrombin III activity in bank-stored blood

Abstract

Coagulation factor VIII and antithrombin III activity were detected in 15 health donors. It was found that antithrombin III activity decreased obviously 12 h after blood drawing. It lost 56 % of the activity at the 3rd day, and 70 % of the activity at the 7th day. FVIII:c showed no obvious change after 24 h, until the 3rd day. It lost 40 % – 60 % of the activity after 36 h and was reduced to the 30 % of the original activity at the 5th day. Our results suggested that at the 3rd day coagulation factor VIII of bank-stored blood can be used to replenish antithrombin III, while bank-stored blood in one day can be used to replenish FVIII.

Keywords

blood storage / antithrombin- III / coagulation factor VIII

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