Pre-clinical experimental studies of indomethacin-releasing copper intrauterine device

Abstract

Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu²⁺ releasing amounts of both IUDsin vitro were observed. The results showed that the inhibiting action of the indomethacinreleasing copper IUD (FICu-IUD) on the PGI₂ was stronger than that on the TXA₂, the ratio of 6-keto-PGF_1a./TXB₂ was reduced with the increase of the doses. There were significant differences between the groups. The FICu-IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu-IUD, and promote copper ion release. It was suggested that in-domethacin released by FICu-IUD could effectively reduce abnormal uterine bleeding.

Keywords

copper intrauterine device / indomethacin / prostaglandins / endothelin / endometrium / copper ion

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