Effects of prostaglandins and leukotrienes on hypoxic pulmonary vasoconstriction in rats

Abstract

To investigate the effects of prostaglandins (PGs) and leukotrienes (LTs) on hypoxic pulmonary vasoconstriction (HPV),in vivo rats experiment andin vitro perfused lung experiment were conducted. The effect of hypoxia on hemodynamics, concentrations of TXB₂ and 6-keto-PGF₁₄ in serum and lung tissue during hypoxia and effects of PGs and LTs on HPV were observed. The results showed that pulmonary arterial pressure (P_pa) and pulmonary vascular resistance were increased during hypoxia, but cardiac output and systemic arterial pressure were decreased. There were increases of the concentrations of TXB₂ and 6-keto-PGF₁₄ and their ratio in serum and lung tissue during hypoxia. After use of cyclooxygenase inhibitor (indomethacin)in vivo andin vitro, HPV was augmented respectively, but after use of lipoxygenase inhibitor (diethylcorbamazine) or leukotriene receptor blocker (LY-171883), HPV was attenuated. It was suggested that LTs mediated pulmonary vasoconstriction, PGs inhibited pulmonary vasoconstriction and they played a modulating role during hypoxia.

Keywords

hypoxia / pulmonary circulation / prostaglandins / leukotrienes

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