Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo

Tao Kaixiong; Chen Daoda; Chen Jianying; Tian Yuan; Wu Zaide; Wang Xiansong; Yang Xiuping

doi:10.1007/BF02886967

Current Medical Science ›› 1999, Vol. 19 ›› Issue (4) : 295 -299. DOI: 10.1007/BF02886967

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Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo

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Abstract

The adriamycin magnetic microspheres (ADM-MAMs) were prepared by the heat-stabilized protein methods. Their physico-chemical properties were examined; their cytotoxicities against tumor cellsin vitro were assayed by a modified MTT method, and their effects were observed on the implanted gastric tumor in Wistar rats given ADM-MAMs via alimentary canal at the presence of the external magnetic fields. The results showed that the ADM-MAMs were successfully prepared and had cytotoxic effect on tumor cellsin vitro similar to the free ADM (P>0. 05). The inhibitory effects of ADM-MAMs on the implanted gastric tumorin vivo were significantly increased as compared with the controls (P<0. 01). Our results suggested that ADM-MAMs were a new type of adriamycin (ADM) preparation and its form alteration did not affect its anticancer effects.

Keywords

adriamycin / magnetic microsphere / preparation / cytotoxicity / implanted gastric tumor / magnetic field

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Tao Kaixiong, Chen Daoda, Chen Jianying, Tian Yuan, Wu Zaide, Wang Xiansong, Yang Xiuping. Preparation of adriamycin magnetic albumin microspheres and their experimental antitumor effectsin vitro andin vivo. Current Medical Science, 1999, 19(4): 295-299 DOI:10.1007/BF02886967

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