The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary

Liu Qin; Bai Xiangjun; Liu Kui; Lin Wen; Lei Ting

doi:10.1007/BF02886962

Current Medical Science ›› 1999, Vol. 19 ›› Issue (9) : 277 -279. DOI: 10.1007/BF02886962

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The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary

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Abstract

Growth hormone releasing peptide (GHRP-2) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by fetal pituitary somatotrophs through a new membrane receptor, which is different from growth hormone releasing hormone (GHRH) and somatostatin (SMS) receptors. We used cell cultures of human fetal pituitary somatotroph cells to investigate the effect of GHRH, GHRP-2 and somatostatin on GH secretion. The results showed that the mechanism of GHRH/SMS and GHRP-2 was different. This indicated that a different intracellular signal transduction system might also play a crucial role in the regulation of GH secretion.

Keywords

fetal pituitary / GH / GHRP-2 / GHRH / somatostatin

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Liu Qin, Bai Xiangjun, Liu Kui, Lin Wen, Lei Ting. The effect of GHRH, GHRP-2 and somatostatin on GH secretion by fetal pituitary. Current Medical Science, 1999, 19(9): 277-279 DOI:10.1007/BF02886962

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