Association between HPV16/18 infection and expression of P53 protein in laryngeal papillomas

Abstract

To understand the relationship between expression of P53 protein and HPV16/18 infection in laryngeal papillomas, PCR and immunohistochemical techniques were used to examine the paraffin-embedded tissue samples of laryngeal papillomas from 35 subjects. HPV 16/18-DNA was found in 24 cases of laryngeal papillomas (68. 8 %). Overexpression of P53 protein was detected in 19 cases (54. 3 %). Both HPV16/18-DNA and overexpression of P53 protein Were demonstrated in 12 cases of laryngeal papillomas (34. 3 %). Our results suggest that HPV16/18 infection and P53 gene mutation are associated with pathogenesis of laryngeal papillomas. The relation between HPV infection and P53 mutation in tissues of laryngeal papillomas remains to be clarified.

Keywords

human papillomavirus / laryngeal papillomas / P53 protein

References

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