Effect of ligustrazine on expression of adherent molecule CD₄₉d and Cyclin D₂ in hematopoietic cells in acute radiation injured mice

Abstract

After irradiation by 8. 0 Gy γ-ray, each mouse was stomach-fed by 4 mg ligustrazine injection twice a day. On the 7th day after irradiation, CD₄₉d expression in ligustrazine-treated group was significantly higher than that in control group (P<0. 01), and showed no difference from that in normal group (P> 0. 05). On the 14th day after irradiation. CD₄₉d expression was increased in control group, but decreased significantly in ligustrazine-treated group (P<0. 01). The expression of Cyclin D₂ in spleen mononuclear cells (MNC) in ligustrazinetreated group was significantly higher than that in control group, but the ratio of G₀+G₁ phase cells was significantly lower in ligustrazine-treated group (P<0. 01). This finding indicated that ligustrazine could increase the expression of adherent molecule on bone marrow hematopoietic cells and Cyclin D₂ in spleen MNC, thereby promoting the growth of hematopoietic cells.

Keywords

ligustrazine / adherent molecule / Cyclins

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