Changes in cardiovascular activity during an increase in biliary tract pressure in rabbits

Abstract

In order to study the mechanism of decreased blood pressure caused by an acute increase in biliary tract pressure, we observed house rabbit model of self-made caecus for changes in cardiovascular function when biliary tract pressure was increased. It was found that both the blood pressure and cardiac output evidently decreased (P<0.05) parallelly, and the systolic pressure decreased more markedly than diastolic pressure. At the same time there was fluctuation in heart rate and in central venous pressure; but there was no significant difference between them (P>0.05), suggesting that in the absence of infective agents, the increased biliary tract pressure can bring about a decrease in cardiac output, which is an important factor contributing to an early blood pressure decrease in acute cholangitis of severe type (ACST).

Keywords

biliary tract / blood pressure / cardiovascular system / cholangitis / pressure

References

[1] HuY H, ZhengQ C. Effect of experimental acute hypertension of the biliary tract on hemodynamics and activity of the major splanchnic nerve in rabbits. J of Tongji Med Univ, 1991, 11(4): 244-244

[2] AttilaCsendes M D. Common bile duct pressure in patients with common duct stones without acute suppurative cholangitis. Arch Surg, 1988, 123696-696

[3] 1991; 7 (6): 656