Effects of cimetidine on IL-2 and T suppressor cell function in rats with obstructive jaundice

Abstract

Susceptibility to infection in patients with obstructive jaundice is much more higher than non-jaundiced patients. The reasons for this are not completely understood. It is postulated that this may have some relation to changes of patients’ immune function. This article reported the changes of splenocyte IL-2 production and T Suppressor cell activity in rats with obstructive jaundice. Meanwhile, we also investigated effects of cimetidine on immune function in rats with bile duct ligation. The results show that IL-2 production in obstructive jaundiced rats significantly decreased and T suppressor cell activity markably increased. Cimetidine could remarkably enhance IL-2 production and suppress T Suppressor cell activity. Abmormaility of immune function may be one reason for high susceptibility to infection in patients with obstructive jaundice in perioperative period. Cimetidine, which could clearly improve immune function in rats with obstructive jaundice, might be a valuable agent for strengthening the capacity of fighting infection in patients with obstructive jaundice.

Keywords

obstructive jaundice interleukin 2 / T suppressor cell / cimetidine / immunoregulation

References

[1] GearingA J H, JohnstoneA P, ThropeR. Production and assay of the Interieukins. J Immunol Methods, 1983, 83: 1-1

[2] LiZ Z, LouD D, WangX H, et al.. Changes in T cell Subsets and T Suppressor cell function and their relationship in human schistosomiasis japonicce. J Tongji Med Uni, 1991, 11(2): 135-135

[3] DunnC W, HortonJ W. Murauyl Dpetide improves mononuclear phagocyte System function in obstructive jaundice. J Surg Res, 1990, 48: 249-249

[4] O’connerAllen M, WiltonP B, BarkaR A, et al.. Effects of biliary obstruction on hepatic clearance of bacteria. Arch Surg, 1989, 12: 973-973

[5] DingJ W, AnderssonR, Stenrumv, et al.. Effects of Biliary decompression on reticuloendothelial function in jaundiced rats. Br J Surg, 1992, 79: 648-648

[6] PintoM, KaplunA. Immune Status in mice with experimental biliary obstruction. Immunol Imunopath, 1980, 16: 396-396

[7] MlinganiM C, GerosaF, CarraG, et al.. Human Interleukin 2 promotes Prolferation of B cell Via surface. recpetors similiar to those of activited T cells. Nuture, 1984, 312: 614-614

[8] RobbR J.. Interleukin 2: the molecule and its function. Immunol Today, 1984, 5(7): 203-203

[9] T NK 1992; 21 (5): 292

[10] HansbroughJ F, Zapata-SirventR L, BenderE M, et al.. Prevention of alternations in postoperative lymphocyte subpopulation by cimitidine and Ibuprofen. Am J Surg, 1986, 151: 249-249

[11] BenderE M, HansbroghJ F, Zapata-SirventR L, et al.. Resorationof immunity in immunity in burned mice by Cimitidine. J Trauma, 1985, 25: 131-131