Effect of Yiqitongyanghuatan recipe on experimental atherosclerosis in rabbits

Abstract

In order to investigate the roles of Yiqitongyanghuatan (YQTYHT) recipe in reducing the levels of serum cholesterol and plasma lipid peroxidation (LPO), platelet aggregation function (PAgF) and platelet adhesion function (PAdF), the area of atherosclerotic plague coverage in aorta and the thickness of plague, 32 male Japanese white rabbits were divided into 4 groups. The results showed that the YQTYHT recipe could significantly lower the levels of serum cholesterol and tryglyceride, plasma LPO, and PAgF and PadF. The area of atherosclerotic plague coverage in aorta and the thickness of plague in the YQTYHT-fed rabbits were decreased as compared with that in the high-cholesterol-fed rabbits. The above roles might contribute to the main mechanism of YQTYHT against atherosclerosis.

Keywords

Yiqitongyanghuatan recipe / atherosclerosis / hyperlipidemia / lipid peroxidation / platelet aggregation functions platelet adhesion function

References

[1] 1984. 102–103

[2] 1994.546–550

[3] 1996.94–96

[4] 1995.30–31

[5] 1995,15(8):480

[6] DenkeM A. Diet and lifestyle modification and its relationship to atherosclerosis. Med Clin North Am, 1994, 78197-197

[7] DenkeM A. Cholesterol-lowering diet. Arch Intern Med, 1995, 15517-17

[8] NilssonJ. Growth factors and the pathogenesis of atherosclerosis, 1986, 62185-185

[9] SteinbergD, ParthasarathyS, GarewT E, et al. . Beyond cholesterol modifications of LDL that increase its atherogenicity. N Engl J Med, 1989, 302915-915