Tumor necrosis factor α, interleukin-6, interluikin-8, and interferon α in children with viral hepatitis

Abstract

To investigate the cellular immunological changes in children with viral hepatitis, interleukin 6 (IL-6), interleukin 8 (IL-8), interferon α (IFN_α), and tumor necrosis factor α (TNF_α) in supernatant of cultured peripheral blood mononuclear cells (PBMCs) of 49 children with hepatitis At B or C were measured. The levels of IL-6, IL-8, TNF_α in PBMCs of the 3 viral hepatitis groups were increased and the level of IFN_α decreased as compared with those of normal control group. But there were no significant differences among the 3 viral hepatitis groups. It was concluded that cellular immunological disorders were related to the onset and the induced damage of the viral hepatitis in children.

Keywords

human viral hepatitis / cytokines / children

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