Pharmacokinetic study on lovastatin sustained-release tablet and sustained-release capsule in Begal dogs

Abstract

This study pharmacokinetically examined the lovastatin sustained-release tablet and sustained-release capsule in Beagle dogs. An reversed-phase HPLC method was established for the determination of lovastatin in Beagle dog plasma. Pharmacokinetic findings were compared among three preparation (lovastatin sustained-release tablet, T_p; sustained-release capsule, T_j and conventional capsule). Our results showed that the pharmacokinetic parameters in 6 dogs after single-dose oral administration of three perparations were calculated. T_max, C_max and MRT revealed significant difference (P<0.05). Relative bioavailability was 111.5±16.9% (T_p) and 110.4%±9.6% (T₁). The pharmacokinetic parameters in the 6 dogs after multiple-dose oral administration of three perparations, T_max, C_max MRT and DF had significant difference (P<0.05); C_av, C_min and AUC_0–24h displayed no significant difference (P>0.05). It is concluded that the lovastatin sustained-release tablet and sustained-release capsule are able to maintain a sustained-release for 24 h.

Keywords

lovastatin / sustained-release tablets / sustained-release capsules / pharmacokinetic / single-dose / multiple-dose

References

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