Studies on the calcium antagonistic action of tetrandrine: II. Effects of tetrandrine on cat papillary muscle

Abstract

1.	Tetrandrine was found to decrease the contractility, ±dT/dtmax and automaticity and prolong the functional refractory period of cat papillary muscle, but it exerted no influence on its excitability.
2.	The above results are in accordance with those we obtained previously in guinea pig atrium.
3.	The negative inotropic and automaticitic effects indicate that tetrandrine might be a calcium influx blocker like verapamil.

Keywords

tetrandrine / cat papillary muscle / calcium antagonist

References

[1] FangDachao, et al. . Studies on the calcium antagonistic action of tetrandrine: I. Effects of tetrandrine on the isolated guinea pig atrium. Acta Academiae Medicinae Wuhan, 1981, 1(2): 46-46

[2] NawrathH, LudwigC. Effects of D₆₀₀ and its optical isomers on force of contraction in cat papillary muscles and guinea pig auricles. Br J Pharmacol, 1977, 59411-411

[3] TaubertK, et al. . Effect of digitalis and calcium on papillary muscle in normal and hypotic states. Am J Physiol, 1976, 23166-66

[4] DreselPE, DuncanDC. Induction of automaticity in cat papillary muscles by sympathomimetic amines. J Pharmacol Exp Ther, 1961, 13370-70

[5] GovierWC. The mechanism of atria refractory period change produced by ouabain. J Pharmacol Exp Ther, 1965, 148100-100

[6] ZbindenG, GrossF. Pharmacological methods in toxicology, 1979, Oxford, London, Pergamon Press: 63-80

[7] 29: 43, 1966

[8] 1979