Wilson's disease and hepatic transplantation

Abstract

To investigate the changes in neurological symptoms and signs, as well as serum copper, serum ceruloplasmin after hepatic transplantation in patients with Wilson's disease, neurological symptoms and signs, serum copper, serum ceruloplasmin before and after hepatic transplantation in 18 patients with Wilson's disease were observed, and those changes were followed up in 20 non-operative controls treated with penicillamine. Our results showed that the neurological symptoms and signs, serum copper and serum ceruloplasmin were improved in the operative group but deteriorated in the non-operative control group. Our study showed that hepatic transplantation is better than penicillamine in the treatment of Wilson's disease.

Keywords

Wilson's disease / hepatic transplantation / clinical investigation

References

[1] ParrilleP, SanchezB F, FiguerasJ, et al. . Analysis of the complications of piggyback technique in 1112 liver transplant. Transplantation, 1999, 671214-1214

[2] GrothC G. Transplantation today. Vol. 2, 1973, Wuhan, Grane Stratton: 829-833

[3] StracciariA, TempestiniA, BorghiA, et al. . Effect of liver transplantation on neurological manifestation in Wilson disease. Arch Neurol, 2000, 57384-384

[4] AsonumaK, InomataY, KascharaM, et al. . Living related liver transplantation from heterozygote genetic carriers to children with Wilsons disease. Pediatr Transplant, 1999, 3201-201

[5] KhannaA, TaniaA, EghtesadB, et al. . Liver transplantation for metabolic liver disease. Surg Clin North Am, 1999, 79153-153

[6] SchumacherG, PlatzK P, MuellerA R, et al. . Liver transplantation treatment of choice for hepatic and neurological manifestation of WD. Clin Transplant, 1997, 11217-217

[7] ChenC L, ChenY S, ChangY C, et al. . Paediatric liver transplantation: a 10 year experience in Taiwan. J Gastroenterol Hepatol, 1996, 1181-81

[8] SchilshyM I, ScheinbergI H, StemliebI, et al. . Liver transplantation for Wilson's disease: indications and outcome. Hepatology, 1994, 19583-583

[9] EghtesadB, NezekatgooN, CeraciL C, et al. . Liver transplantation for Wilson's disease. Liver Transplant Surg, 1999, 5467474-467474