Low and maternal-specific expression of p57^KIP2 in hydatidiform mole and its clinical implication

Abstract

In situ hybridization was applied to locate and detect the expression of p57^KIP2 in hydatidiform mole (5 cases of partial hydatidiform mole and 18 cases of complete hydatidiform mole) and normal villi (23 cases). The positive signals of p57^KIP2 expression were analyzed by HPIAS-1000 Image-Analysis System. p57^KIP2 was highly expresed in normal villi but showed distinct low expression in hydatidiform mole (P<0.01). Furthermore, the locus of low expression of p57^KIP2 accorded with the place where lesion of trophoblast occurred. Detection of p57^KIP2 made it possible to study the genetics of hydatidiform mole at the transcriptional level. Low expression of p57^KIP2 could be a molecular marker in hydatidiform mole and a target for therapy.

Keywords

p57^KIP2 / hydatidiform mole / in situ hybridization

References

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