Effects of dauricine on the physiologic properties of myocardium

Abstract

Effects of dauricine (Dau) on the physiologic properties of myocardium were studied in cat papillary muscles. Dau (32 μM) decreased the force of contraction to 72 ±3 % (P<0.01) and depressed markedly the excitability as well as epinephrine-induced automaticity, even in lower concentration (5 μM). It also prolonged the functional refractory period from 315±13 ms to 362±18 ms (P< 0.05). The results obtained indicate that Dau possesses calcium antagonistic effect as well as an inhibitory action on Na⁺ current in cat papillary muscles.

Keywords

dauricine / cat papillary muscle / calcium antagonist

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