Inhibitory action of chinese medicinal preparation — Anti-inflammatory Agent No. 6— on DIC resulting from endotoxin: Experimental study

Abstract

Anti-inflammatory Agent No. 6 is an effective preparation in treating many infectious diseases. It is made from Chinese medicinal herbs according to Traditional Chinese Medicine (TCM) theories. A rabbit model of DIC was established by injecting endotoxin of colibacilli. The mentioned agent was then administered to this model to observe its inhibitory action on the pathophysiological processes of DIC. The mechanism of its action might be the result of direct effect of degradation on endotoxin and intensification of phagocytosis of MPS. Thus, in TCM theory so-called “heat clearing and detoxifying properties” can be preliminarily interpreted by modern scientific investigations.

Keywords

Chinese medicinal herbs / Anti-inflammatory Agent No. 6 / endotoxin / DIC / detoxifying

References

[1] 6 200 1975; (1): 83–8.

[2] 6 282 6 1983; 11–9.

[3] 6 1977; (6): 7–14.

[4] 6 1980; (2): 65–7.

[5] 6 6 1983; 1–6.

[6] 1979; 386–9.

[7] 1979; 70–1.

[8] ColmanRW, et al. . Disseminated intravascular coagulation (DIC): An approach. Am J Med, 1972, 52679-89

[9] 1982; 1472 013;9.

[10] Putt FA. Manual of Histopathologicai Staining Methods. Wiley, New York, 1972; 94–5.

[11] Culling CFA. Handbook of Histopathological and Histochemical Techniques. ed 3, Butter Worth & Co, 1974; 217–8.

[12] LatourJG, et al. . Prevention of the generalized Shwartzman reaction by glucocorticoids. Am J Obstet Gynecol, 1972, 113(7): 863-7

[13] LatourJG, et al. . Corticosteroids and the generalized Shwartzman reaction. Am J Pathol, 1971, 65(1): 189-201

[14] LopesJ, InnissWE. Electron microscopy of effect of polymyxin on escherichia coli lipopolysaccharide. J Bacteriol, 1969, 75(3): 1128-9