Chromosomal changes in acute promyelocytic leukemia

Abstract

In this study cytogenetic analysis of 5 cases of acute promyelocytic leukemia (APL) is described and 3 (60%) of them showed t(15; 17) in karyotype. In recent years more than 130 cases of hematological disorders were studied cytogenetically in our laboratory and this kind of translocation has not been found except in APL. As shown in these patients t(l5; l7) might occur in adults as well as in children and likewise in patients with or without DIC. The chromosome study by G-banding technique demonstrated that the breakpoint of chromosome No. 15 was located between q²⁴ and q²⁵, and that of chromosome No. 17 was located at q²¹. The structural rearrangement was reported as rcp(15;17) (q²⁵⁰⁰; q^2102?).

Keywords

acute promyelocytic leukemia / chromosome / translocation / G-banding

References

[1] RowleyJD. The cytogenetics of acute leukemia. Clin Haematol, 1978, 7385-385

[2] RowleyJD, et al. . 15/17 translocation, a consistent chromosomal change in acute promyelocytic leukemia. Lancet, 1977, 1549-50

[3] Second International Workshop on Chromosomes in Leukemia. Chromosomes in acute promyelocytic leukemia. Cancer Genet Cytogenet, 1980, 2103-103

[4] BennettJM, et al. . Proposals for the classification of the acute leukemias. Br J Haematol, 1976, 33451-8

[5] 1981; 4(1): 44.

[6] Standing Committee on Human Cytogenetic Nomenclature. An international system for human cytogenetic nomenclature (ISCN, 1978). Cytogenet Cell Genet, 1978, 21309-309

[7] TeerenhoviL, et al. . Uneven geographical distribution of 15/17 translocation in acute promyelocytic leukemia. Lancet, 1978, 2797-97

[8] RowleyJD. Chromosome changes in leukemia. Br J Haematol, 1980, 44339-45

[9] OkadaM, et al. . 15/17 translocation in acute promyelocytic leukemia. Lancet, 1977, 1961-61

[10] KanekoY, et al. . 15/17 translocation in acute promyelocytic leukemia. Lancet, 1977, 1961-61

[11] Van den BergheH, et al. . Chromosome abnormalities in promyelocytic leukemia (APL). Cancer, 1979, 43558-62

[12] Dela ChapelleA, et al. . Chromosomal abnorm alities in acute promyelocytic leukemia. Scand J Haematol, 1981, 2657-60