General level and distribution of the intra-and extra-erythrocytes sodium concentration in a population and their relationship with blood pressure

Abstract

This paper reports a cross-sectional survey in a defined population. The level and distribution of intraerythrocyte sodium ions (Na⁺_i) and extraerythrocyte sodium ions (Na⁺e) of 221 male and female workers were studied and their relationship with blood pressure was analysed by multiple and step-wise regression. The results suggested that: (1) A part of hypertensives and their descendents with normal blood pressure had abnormal sodium transport phenomenon in their erythrocytes membrane. (2) Plasma Na⁺ concentration was positively correlated with the blood pressure of normotensives especially those with family hypertension history. (3) The difference between Na⁺_i and Na⁺_e concentrations was negatively correlated with blood pressure (especially on SBP) of the descendents of hypertensives. (4) These effects were much greater than those produced by known factors such as sex, age, weight and height.

Keywords

+^e')">Na₊^e / +ⁱ')">Na₊ⁱ / +^e-i')">Na₊^e-i / cellular membrane / hypertension

References

[1] BeilinLJ, et al. . The sodium, potassium and water contents of red blood cells of healthy human adults. J Clin Invest, 1966, 45(11): 1817-25

[2] EdmonsonRPS, et al. . Abnormal leuco cytes composition and sodium transport in essential hypertension. Lancet, 1975, 11003-5

[3] BalfeJW, et al. . A hereditary sodium transport defect in the human red blood cell. J Clin Invest, 1968, 474a-4a

[4] GarayRP, et al. . An inherited sodium ion-potassium ion cotransport defect in essential hypertension. Clin Sci, 1980, 59191-3

[5] Aderounmu AF, et al. Abnormal cation composition and transport in erythrocytes from hypertensive patients. Eur J Clin Invest 1979; (7): 369–75.

[6] GarayRP, et al. . Inherited defect in a Na⁺, K⁺-co-transport system in erythrocytes from essential hypertensive patients. Nature, 1980, 284(5753): 281-3

[7] Garay RP, et al. A new test showing abnormal net Na⁺ K⁺ fluxes in erythrocytes of essential hypertensive patients. Lancet 1979; (8112): 349–53.

[8] CanessaM, et al. . Increased sodiumlithium countertransport in red cells of patients with essential hypertension. New Engl J Med, 1980, 902(14–26): 772-6

[9] 1981; 10(4): 86.

[10] 1983;(2) 145–8.