Basic fibroblast growth factor and fibroblast growth factor receptor-1 in human meningiomas

Abstract

The expression of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) in human meningiomas and the relationships between their expression and the tumors' histological features and angiogenesis were investigated by means of immunohistochemical technique. The expression of bFGF and FGFR-1 was detected by antibody of bFGF or FGFR-1. the tumors' angiogenesis was evaluated by microvascular density (MVD) and, which was observed by use of CD34-antibody immunohistochemically. The results showed that there were varied degrees of the expression of bFGF and FGFR-1 proteins in meningiomas. The expression was correlated with the tumors' histological characters and angiogenesis. It was concluded that bFGF and FGFR-1 might play important roles in meningiomas' angiogenesis and proliferation. The expression positive rate of bFGF and FGFR-1 may provide an indication of evaluating the histological and malignant degree of the tumor.

Keywords

meningiomas / basic fibroblast growth factor / fibroblast growth factor receptor-1 / microvascular density / immunohistochemistry

References

[1] CronauerM V, SchulzW A, SeifertH H, et al. . Fibroblast growth factors and their receptors in urological cancers: basic research and clinical implications. Eur Urol, 2003, 43(3): 309-309

[2] WangJ H, PuP Y, WangG X, et al. . Gene expression of bFGF and angiogenesis of human glioma. J Clin Oncol Chin (Chinese), 1999, 26(2): 168-168

[3] BianX W, DuL L, ShiJ Q, et al. . Correlation of bFGF, FGFR-1 and VEGF expression with vascularity and malignancy of human astrocytomas. Anal Quant Cytol Histol, 2000, 22(3): 267-267

[4] KleihuesP, LouisD N, ScheithauerB W, et al. . The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol, 2002, 61(3): 215-215

[5] XuJ L, LaiR, KinoshitaT, et al. . Proliferation, apoptosis, and intratumoral vascularity in multiple myeloma: correlation with the clinical stage and cytological grade. J Clin Pathol, 2002, 55(7): 530-530

[6] JuricG, ZarkovicN, NolaM, et al. . The value of cell proliferation and angiogenesis in the prognostic assessment of ovarian granulosa cell tumors. Tumori, 2001, 87(1): 47-47

[7] OffersenB V, BorreM, OvergaardJ. Quantification of angiogenesis as a prognostic marker in human carcinomas: a critical evaluation of histopathological methods for estimation of vascular density. Eur J Cancer, 2003, 39(7): 881-881

[8] GospodarowiczD, ChengJ, LuiG M, et al. . Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor. Proc Natl Acad Sci USA, 1984, 81(22): 6963-6963