Expression of CD40 and CD40L on peripheral blood monoculear cells in patients with condyloma acuminatum

Abstract

To observe the expression of CD40/CD40L on peripheral blood mononuclear cells (PBMC) in patients with condyloma acuminatum (CA), flow cytometry was employed to examine the expression of CD40 and CD40L on PMBC in 36 patients with CA and 20 healthy controls. Our results showed that mean level of CD40 expression in CA patients was significantly lower than that in the controls (6.58%±2.74% vs 14.81%±6.12%,t=5.703,P<0.05); the average level of CD40L in CA patients was also significantly lower than that in the controls (0.73%±0.54% vs 2.67±2.43%,t=3.532,P<0.05). Our results suggest that the reduced costimulatory interaction of CD40 and CD40L in CA patients may be one of the important factors responsible for the low cellular immunity.

Keywords

condyloma acuminatum / antigens / CD40 / CD40 ligand

References

[1] FrazerI H. The role of the immune system in anogenital human papillomavirus. Australas J Dermatol, 1998, 39(Suppl 1): 5-7

[2] ZarconeR, BelliniP, CardoneG, et al.. Vulvo-vaginal HPV infection, immunological aspects. Minerva Ginecol, 1996, 48(3): 61-3

[3] MatorrasR, AricetaJ M, RementeriaA, et al.. Human immunodeficiency virus-induced immunosuppression: a risk factor for human papillomavirus infection. Am J Obstet Gynecol, 1991, 164(1): 42-4

[4] FrazerI H. Immunology of papillomavirus infection. Curr Opin Immunol, 1996, 8(4): 484-91

[5] FrazerI H, ThomasR, ZhouJ, et al.. Potential strategies utilised by papillomavirus to evade host immunity. Immunol Rev, 1999, 168: 131-132

[6] DiehlL, Den BoerA T, van der VoortE I, et al.. The role of CD40 in peripheral T cell tolerance and immunity. J Mol Med, 2000, 8(7): 363-71

[7] SunY, PengD, LecandaJ, et al.. In vivo gene transfer of CD40 ligand into colon cancer cells induces local production of cytokines and chemokines, tumor eradication and protective antitumor immunity. Gene Ther, 2000, 7(17): 1467-76