Therapeutic effect of propofol in the treatment of endotoxin-induced shock in rats

Abstract

To assess the potential therapeutic effect of propofol in the treatment of endotoxemia, 76 rats were randomly assigned to 5 groups: control group (A), endotoxemic group (B), pre-treatment group (C), simultaneous treatment group (D) and post-treatment group (E). Five h after endotoxin injection, PO₂, pH, MAP, plasma concentrations of Nitrite/nitrate (NO₂⁻/NO₃⁻) and mortality rates were assessed in each group. After the rats were sacrificed, lung tissue was sampled to measure myeloperoxidase (MPO) activity and tumor necrosis factor (TNF)-α contents. It was found that endotoxin injection produced progressive hypotension, metabolic acidosis, and a large increase in the plasma NO₂⁻/NO₃⁻ concentrations and increased mortality rates in 5h. Endotoxin injection significantly increased MPO activity and TNF-α contents in lung tissue (P<0.01 orP<0.05). These changes response to endotoxin were significantly attenuated in the groups B, C and D. But these beneficial effects were blunted in the group E. The results suggest that propofol administration may offer advantages in endotoxemia.

Keywords

propofol / endotoxemia / myeloperoxidase / tumor necrosis factor-α / nitric oxide

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