Effect of catecholamine on central serous chorioretinopathy

Abstract

The role of catecholamine (CA) in the pathogenesis and development of macular edema of central serous chorioretinopathy (CSC) was studied, and its relations with visual acuity were investigated. Plasma concentrations of epinephrine (E) and norepinephrine (NE) were determined in 30 consecutive eyes with CSC. Central macular thickness analysis was done by RTA and all the data were compared with normal eyes and analyzed with SAS software package. Plasma concentrations of E and NE were increased to (569±123) ng/L and (721±104) ng/L respectively in active CSC patients, significantly higher than those in normal subjects (P<0.01), and decreased to normal in convalescent stage. RTA analysis revealed that the retinal thickness of CSC patients was increased at active and recovery stage as compared with normal subjects; and the plasma concentration of E was significantly correlated with central macular thickness (t=2.173,P<0.05). Also, central macular thickness measured by RTA was significantly correlated with the visual acuity (r=−0.8046,P<0.001) in CSC eyes. RTA analysis might be useful to quantitatively detect and evaluate prognosis in CSC patients. The plasma concentration of E, which was highly correlated with macular edema, might play an important role in the early damage and the pathogenesis of CSC.

Keywords

catecholamine / epinephrine / central serous chorioretinopathy / retinal thickness / visual acuity

References

[1] GassJ M D. Pathogenesis of disciform detachment of the neuroepithelium: II. Idiopathic central serous choroidopathy. Am J Ophthalmol, 1967, 63: 587-587

[2] YannuzziL A. Type-A behavior and central serous choriortinopathy. Retina, 1987, 7: 111-111

[3] YoshiocaH, KatsumeY, AkuneH. Experimental central serous chorioretinopathy in monkey eyes: fluorescein angiographic findings. Ophthalmologica, 1982, 185: 168-168

[4] WesterinkB H, BoskerF J, O’HanlonJ F. Use of alumina, sephadex G10, and ion-exchange columns to purify samples for determination of epinephrine, norepinephrine, dopamine, homovanillic acid, and 5—hydroxyin-doleacetic acids in urine. Clin Chem, 1982, 28: 1745-1745

[5] ZeimerR, ShahidiM, MoriM T, et al.. A new method for rapid mapping of the retinal thickness at the posterior pole. Invest Ophthalmol Vis Sci, 1996, 37: 1994-1994

[6] OshimaY, EmiK, YamanishiS, et al.. Quantitative assessment of macular thickness in normal subjects and patients with diabettic retinopathy by scanning retinal thickness analyzer. Br J Ophtalmol, 1999, 83: 54-54

[7] PrünteChristian, FlammerJosef. Choroidal capillary and venous congestion in central serous chorioretinopathy. Am J Ophthalmol, 1996, 121: 26-26