Predicting endometrium receptivity with parameters of spiral artery blood flow

Abstract

In order To evaluate whether the parameters of spiral artery blood flow, as measured by transvaginal color Doppler, may be used to assess endometrium receptivity prior to embryo transfer (ET), a retrospective study of 94 infertile women who had undergone ART treatments with different outcomes (pregnant or nonpregnant) was done. Subendometrial blood flow was evaluated. The resistance index (RI), systolic/diastolic ratio (S/D) and pulsatility index (PI) were significantly lower in those who achieved pregnancy as compared with those who did not: 0.62±0.04 vs 0.68±0.04. (P<0.001), 2.66±0.33 vs 3.19±0.39 (P<0.01) and 1.15±0.17 vs 1.34±0.22 (P<0.05), respectively. Furthermore, when RI>0.72,PI>1.6, and S/D>3.6, no pregnancy occurred. These data suggest that the parameters of spiral artery blood flow could be used as a new assay in predicting endometrial receptivity before ET.

Keywords

endometrium receptivity / parameters of spiral artery blood flow / infertility / transvaginal color Doppler

References

[1] RagaF, Bonilla-MusolesF, CasaE M, et al.. Assessement of endometrial volume by three-dimensional ultrasound prior to embryo transfer: Clues to endometrial receptiveity. Hum Reprod, 1999, 11: 2851-2851

[2] Gong X H, Le G R, Zhang Q Pet al. Application of transvaginal color Doppler in in-vitro fertilization and embryo transfer (Chinese), 2001, 8: 499

[3] GonenY, CasperR F, JacobsonW, et al.. Endometrial thickness and growth during ovarian stimulation: a possible predictor of implantation in IVF. Fertil Steril, 1989, 52: 446-446

[4] GoswamyR K, SteptoeP C. Doppler ultrasound studies of the uterine artery in spontaneous ovarian cycles. Human Reprod, 1988, 3: 721-721

[5] KurjakA, KupesicS, SchulmanH, et al.. Transvaginal color flow Doppler in the assessment of ovarian and uterine blood flow in infertile women. Fertil Steril, 1991, 56: 870-870

[6] SterzikK, HtterW, GrabD, et al.. Doppler sonographic findings and their correlation with implantation in an IVF program. Fertil Steril, 1989, 52: 825-825

[7] SteerC V, MillsC, CampbellS, et al.. The use of transvaginal color flow imaging after IVF to identify optimum uterine conditions before embryo transfer. Fertil Steril, 1992, 57: 372-372

[8] KupesicS, KurjakA. Uterine and ovarian perfusion during the periovulatory period assessed by transvaginal color Doppler. Fertil Steril, 1993, 60: 439-439

[9] YaronY, KogosowskiA, BotchanA, et al.. Endometrial receptivity: the age-related decline in pregnancy rates and the effect of ovarian function. Fertil Steril, 1993, 60: 314-314

[10] GoswamyR K, SteptoeP C. Decreased uterine perfusion: a cause of infertility. Human Reprod, 1988, 3: 955-955

[11] CacciatoreB, SimbergN, FusaroP A, et al.. Transvaginal Doppler study of uterine artery blood flow in in vitro fertilization cycles. Fertil Steril, 1996, 66: 130-130