Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits

Zhang Yi; Luo Hongyan; Liu Shenghong; Yi Zhengrong; Li Ai; Hu Xinwd; Liu Changjin; Tang Ming; Liu Lieju; Song Yuanlong; Gao Linlin

doi:10.1007/BF02828137

Current Medical Science ›› 2005, Vol. 25 ›› Issue (11) : 263 -264. DOI: 10.1007/BF02828137

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Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits

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Abstract

This experiment aimed to investigate the effect of adrenergic system in the subnucleus commissuriu of nucleus solitrius tractus (CNTS) on renal nerve discharges. Norepinephrine (NE) was microinjected into the CNTS of rabbits and mean arterial blood pressure (MAP) and renal nerve discharges (FRND) were synchronously recorded. The results indicated that (1) microinjection of norepinephine into the CNTS of rabbit could significantly attenuate the frequency of renal nerve discharge, and at the same time decrease markedly the mean arterial pressure. (2) Microinjection of 0.3 nmol yohimbin into CNTS had no significant influence on FRND and MAP, but could attenuate and even reverse the effects of NE on FRND and MAP. These results suggest that micro-injection of NE into CNTS may activate the alpha-adrenorecptor located in CNTS and secondarily produce a depressor effect by attenuating the activity of peripheral sympathetic nervous system.

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subnucleus commissurius of nucleus solitarius tractus / norepinephrine / arterial pressure / renal nerve discharge

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Zhang Yi, Luo Hongyan, Liu Shenghong, Yi Zhengrong, Li Ai, Hu Xinwd, Liu Changjin, Tang Ming, Liu Lieju, Song Yuanlong, Gao Linlin. Mechanisms of depressor effect of norepinephrine injected into subnucleus commissuriu of nucleus solitarius tractus in rabbits. Current Medical Science, 2005, 25(11): 263-264 DOI:10.1007/BF02828137

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