Changes of expression of stretch-activated potassium channel TREK-1 mRNA and protein in hypertrophic myocardium

Cheng Longxian; Su Fangebeng; Ripen Nsenga; Fan Hong; Huang Kai; Wang Min; Peng Hongyu; Mei Chunli; Zhao Fang; Liao Yuhua

doi:10.1007/BF02828031

Current Medical Science ›› 2006, Vol. 26 ›› Issue (9) : 31 -33. DOI: 10.1007/BF02828031

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Changes of expression of stretch-activated potassium channel TREK-1 mRNA and protein in hypertrophic myocardium

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Abstract

The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coaretation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi quantitative RT PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy. As compared to sham operated group, stretch activated potassium channel TREK-1 mRNA was strongly expressed and protein was up regulated in operation groups (P<0.05). It was concluded that the expression of TREK 1 was up regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats.

Keywords

hypertrophic myocardium / stretch activated potassium channel / ventricular remodeling / electrical remodeling

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Cheng Longxian, Su Fangebeng, Ripen Nsenga, Fan Hong, Huang Kai, Wang Min, Peng Hongyu, Mei Chunli, Zhao Fang, Liao Yuhua. Changes of expression of stretch-activated potassium channel TREK-1 mRNA and protein in hypertrophic myocardium. Current Medical Science, 2006, 26(9): 31-33 DOI:10.1007/BF02828031

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