Cancer Communications >

2024 , Vol. 44 >Issue 2: 287 - 293

DOI: https://doi.org/10.1002/cac2.12498

Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses

  • Kouya Shiraishi , 1,2 ,
  • Atsushi Takahashi 3,4 ,
  • Yukihide Momozawa 5 ,
  • Yataro Daigo 6,7 ,
  • Syuzo Kaneko 8 ,
  • Takahisa Kawaguchi 9 ,
  • Hideo Kunitoh 10 ,
  • Shingo Matsumoto 11 ,
  • Hidehito Horinouchi 12 ,
  • Akiteru Goto 13 ,
  • Takayuki Honda 14 ,
  • Kimihiro Shimizu 15,16 ,
  • Masahiro Torasawa 1,12 ,
  • Daisuke Takayanagi 1 ,
  • Motonobu Saito 17 ,
  • Akira Saito 18 ,
  • Yuichiro Ohe 12 ,
  • Shun-ichi Watanabe 19 ,
  • Koichi Goto 11 ,
  • Masahiro Tsuboi 20 ,
  • Katsuya Tsuchihara 21 ,
  • Sadaaki Takata 5 ,
  • Tomomi Aoi 5 ,
  • Atsushi Takano 6 ,
  • Masashi Kobayashi 22 ,
  • Yohei Miyagi 23 ,
  • Kazumi Tanaka 16 ,
  • Hiroyuki Suzuki 24 ,
  • Daichi Maeda 13 ,
  • Takumi Yamaura 24 ,
  • Maiko Matsuda 1 ,
  • Yoko Shimada 1 ,
  • Takaaki Mizuno 1,12 ,
  • Hiromi Sakamoto 25 ,
  • Teruhiko Yoshida 26 ,
  • Yasushi Goto 12 ,
  • Tatsuya Yoshida 12 ,
  • Taiki Yamaji 27 ,
  • Makoto Sonobe 28 ,
  • Shinichi Toyooka 29 ,
  • Kazue Yoneda 30 ,
  • Katsuhiro Masago 31 ,
  • Fumihiro Tanaka 30 ,
  • Megumi Hara 32 ,
  • Nobuo Fuse 33 ,
  • Satoshi S. Nishizuka 34 ,
  • Noriko Motoi 35 ,
  • Norie Sawada 27 ,
  • Yuichiro Nishida 32 ,
  • Kazuki Kumada 33 ,
  • Kenji Takeuchi 36 ,
  • Kozo Tanno 34 ,
  • Yasushi Yatabe 35 ,
  • Kuniko Sunami 1 ,
  • Tomoyuki Hishida 20,37 ,
  • Yasunari Miyazaki 14 ,
  • Hidemi Ito 38 ,
  • Mitsuhiro Amemiya 18 ,
  • Hirohiko Totsuka 18 ,
  • Haruhiko Nakayama 39 ,
  • Tomoyuki Yokose 40 ,
  • Kazuyoshi Ishigaki 3 ,
  • Toshiteru Nagashima 16 ,
  • Yoichi Ohtaki 16 ,
  • Kazuhiro Imai 41 ,
  • Ken Takasawa 8 ,
  • Yoshihiro Minamiya 41 ,
  • Kazuma Kobayashi 8 ,
  • Kenichi Okubo 22 ,
  • Kenji Wakai 36 ,
  • Atsushi Shimizu 34 ,
  • Masayuki Yamamoto 33 ,
  • Motoki Iwasaki 27,42 ,
  • Koichi Matsuda 43 ,
  • Johji Inazawa 44 ,
  • Yuichi Shiraishi 45 ,
  • Hiroyoshi Nishikawa 46 ,
  • Yoshinori Murakami 47 ,
  • Michiaki Kubo 5 ,
  • Fumihiko Matsuda , 9 ,
  • Yoichiro Kamatani , 3 ,
  • Ryuji Hamamoto , 8 ,
  • Keitaro Matsuo , 48 ,
  • Takashi Kohno , 1
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  • 1. Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan
  • 2. Department of Clinical Genomics, National Cancer Center Research Institute, Tokyo, Japan
  • 3. Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
  • 4. Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Osaka, Japan
  • 5. Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan
  • 6. Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • 7. Department of Medical Oncology and Cancer Center, and Center for Advanced Medicine against Cancer, Shiga University of Medical Science, Otsu, Japan
  • 8. Division of Medical AI Research and Development, National Cancer Center Research Institute, Tokyo, Japan
  • 9. Center for Genomic Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  • 10. Department of Medical Oncology, Japanese Red Cross Medical Center, Tokyo, Japan
  • 11. Department of Thoracic Oncology, National Cancer Center Hospital East, Japan
  • 12. Department of Thoracic Oncology, National Cancer Center Hospital, Tokyo, Japan
  • 13. Department of Cellular and Organ Pathology, Graduate School of Medicine, Akita University, Akita, Japan
  • 14. Department of Respiratory Medicine, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
  • 15. Division of General Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
  • 16. Department of General Surgical Science, Division of General Thoracic Surgery, Gunma University Graduate School of Medicine, Integrative Center of General Surgery, Gunma University Hospital, Gunma, Japan
  • 17. Department of Gastrointestinal Tract Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
  • 18. StaGen Co., Ltd, Tokyo, Japan
  • 19. Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
  • 20. Department of Thoracic Surgery, National Cancer Center Hospital East, Chiba, Japan
  • 21. Division of Translational Informatics, Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Chiba, Japan
  • 22. Department of Thoracic Surgery, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan
  • 23. Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa, Japan
  • 24. Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
  • 25. Fundamental Innovative Oncology Core Center, National Cancer Center Research Institute, Tokyo, Japan
  • 26. Department of Genetic Medicine and Services, National Cancer Center Hospital, Tokyo, Japan
  • 27. Division of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo, Japan
  • 28. Department of Thoracic Surgery, Kyoto University Hospital, Kyoto, Japan
  • 29. Departments of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
  • 30. Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
  • 31. Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
  • 32. Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan
  • 33. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
  • 34. Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Iwate, Japan
  • 35. Department of Diagnostic Pathology, National Cancer Center Hospital, Tokyo, Japan
  • 36. Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
  • 37. Division of Thoracic Surgery, Department of Surgery, Keio University School of Medicine, Tokyo, Japan
  • 38. Division of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya, Japan
  • 39. Department of Thoracic Surgery, Kanagawa Cancer Center, Kanagawa, Japan
  • 40. Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan
  • 41. Department of Thoracic Surgery, Graduate School of Medicine, Akita University, Akita, Japan
  • 42. Division of Cohort Research, National Cancer Center Institute for Cancer Control, Tokyo, Japan
  • 43. Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Science, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan
  • 44. Department of Molecular Cytogenetics, Medical Research Institute and Bioresource Research Center, Tokyo Medical and Dental University, Tokyo, Japan
  • 45. Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan
  • 46. Division of Cancer Immunology, Research Institute, National Cancer Center, Tokyo, Japan
  • 47. Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  • 48. Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan
kshirais@ncc.go.jp
fumi@genome.med.kyoto-u.ac.jp
yoichiro.kamatani@riken.jp
rhamamot@ncc.go.jp
kmatsuo@aichi-cc.jp
tkkohno@ncc.go.jp

Received date: 25 May 2023

Revised date: 06 Oct 2023

Accepted date: 15 Oct 2023

Published date: 20 Feb 2024

Copyright

2023 2023 The Authors. Cancer Communications published by JohnWiley & Sons Australia, Ltd on behalf of SUN YAT-SEN UNIVERSITY CANCER CENTER.
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Cite this article

Kouya Shiraishi , Atsushi Takahashi , Yukihide Momozawa , Yataro Daigo , Syuzo Kaneko , Takahisa Kawaguchi , Hideo Kunitoh , Shingo Matsumoto , Hidehito Horinouchi , Akiteru Goto , Takayuki Honda , Kimihiro Shimizu , Masahiro Torasawa , Daisuke Takayanagi , Motonobu Saito , Akira Saito , Yuichiro Ohe , Shun-ichi Watanabe , Koichi Goto , Masahiro Tsuboi , Katsuya Tsuchihara , Sadaaki Takata , Tomomi Aoi , Atsushi Takano , Masashi Kobayashi , Yohei Miyagi , Kazumi Tanaka , Hiroyuki Suzuki , Daichi Maeda , Takumi Yamaura , Maiko Matsuda , Yoko Shimada , Takaaki Mizuno , Hiromi Sakamoto , Teruhiko Yoshida , Yasushi Goto , Tatsuya Yoshida , Taiki Yamaji , Makoto Sonobe , Shinichi Toyooka , Kazue Yoneda , Katsuhiro Masago , Fumihiro Tanaka , Megumi Hara , Nobuo Fuse , Satoshi S. Nishizuka , Noriko Motoi , Norie Sawada , Yuichiro Nishida , Kazuki Kumada , Kenji Takeuchi , Kozo Tanno , Yasushi Yatabe , Kuniko Sunami , Tomoyuki Hishida , Yasunari Miyazaki , Hidemi Ito , Mitsuhiro Amemiya , Hirohiko Totsuka , Haruhiko Nakayama , Tomoyuki Yokose , Kazuyoshi Ishigaki , Toshiteru Nagashima , Yoichi Ohtaki , Kazuhiro Imai , Ken Takasawa , Yoshihiro Minamiya , Kazuma Kobayashi , Kenichi Okubo , Kenji Wakai , Atsushi Shimizu , Masayuki Yamamoto , Motoki Iwasaki , Koichi Matsuda , Johji Inazawa , Yuichi Shiraishi , Hiroyoshi Nishikawa , Yoshinori Murakami , Michiaki Kubo , Fumihiko Matsuda , Yoichiro Kamatani , Ryuji Hamamoto , Keitaro Matsuo , Takashi Kohno . Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses[J]. Cancer Communications, 2024 , 44(2) : 287 -293 . DOI: 10.1002/cac2.12498

References

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1
SunS, Schiller JH, GazdarAF. Lung cancer in never smokers–a different disease. Nat Rev Cancer 2007;7(10):778–790.

2
ShiraishiK, OkadaY, TakahashiA, Kamatani Y, MomozawaY, AshikawaK, et al. Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun 2016;7:12451.

3
McKayJD, HungRJ, HanY, ZongX, Carreras-TorresR, ChristianiDC, et al. Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. Nat Genet 2017;49(7):1126–1132.

4
ShiJ, Shiraishi K, ChoiJ, MatsuoK, ChenTY, DaiJ, et al. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population. Nat Commun 2023;14(1):3043.

5
ByunJ, HanY, LiY, XiaJ, LongE, Choi J, et al. Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. Nat Genet 2022;54(8):1167–1177.

6
BlackburnEH, EpelES, LinJ. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science 2015;350(6265):1193–1198.

7
DeBoyEA, TassiaMG, SchratzKE, Yan SM, CosnerZL, McNallyEJ, et al. Familial Clonal Hematopoiesis in a Long Telomere Syndrome. N Engl J Med 2023;388(26):2422–2433.

8
MarkozannesG, Kanellopoulou A, DimopoulouO, KosmidisD, ZhangX, WangL, et al. Systematic review of Mendelian randomization studies on risk of cancer. BMC Med 2022;20(1):41.

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