Neuroinflammation drives apathy in cancer cachexia

Cancer Communications ›› 2025, Vol. 45 ›› Issue (10) : 1334 -1337. DOI: 10.1002/cac2.70055

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Bingjun Ha, Xuetao Cao. Neuroinflammation drives apathy in cancer cachexia. Cancer Communications, 2025, 45(10): 1334-1337 DOI:10.1002/cac2.70055

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[1]	Pu T, Sun J, Ren G, Li H. Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications. Signal Transduction and Targeted Therapy. 2025; 10(1): 176.

[2]	Padmanaban V, Keller I, Seltzer ES, Ostendorf BN, Kerner Z, Tavazoie SF. Neuronal substance P drives metastasis through an extracellular RNA–TLR7 axis. Nature. 2024; 633(8028): 207-15.

[3]	Setiawan T, Sari IN, Wijaya YT, Julianto NM, Muhammad JA, Lee H, et al. Cancer cachexia: molecular mechanisms and treatment strategies. Journal of Hematology & Oncology. 2023; 16(1): 54.

[4]	Xin Z, Qin L, Tang Y, Guo S, Li F, Fang Y, et al. Immune mediated support of metastasis: Implication for bone invasion. Cancer Communications. 2024; 44(9): 967-91.

[5]	Brudno JN, Kochenderfer JN. Current understanding and management of CAR T cell-associated toxicities. Nature Reviews Clinical Oncology. 2024; 21(7): 501-21.

[6]	Menard C, Pfau ML, Hodes GE, Kana V, Wang VX, Bouchard S, et al. Social stress induces neurovascular pathology promoting depression. Nature Neuroscience. 2017; 20(12): 1752-60.

[7]	Zhu XA, Starosta S, Ferrer M, Hou J, Chevy Q, Lucantonio F, et al. A neuroimmune circuit mediates cancer cachexia-associated apathy. Science. 2025; 388(6743): eadm8857.

[8]	Campos CA, Bowen AJ, Han S, Wisse BE, Palmiter RD, Schwartz MW. Cancer-induced anorexia and malaise are mediated by CGRP neurons in the parabrachial nucleus. Nature Neuroscience. 2017; 20(7): 934-42.

[9]	Zhang C, Vincelette LK, Reimann F, Liberles SD. A brainstem circuit for nausea suppression. Cell Reports. 2022; 39(11): 110953.

[10]	Sun Q, van de Lisdonk D, Ferrer M, Gegenhuber B, Wu M, Park Y, et al. Area postrema neurons mediate interleukin-6 function in cancer cachexia. Nature Communications. 2024; 15(1): 4682.