Single-cell-eQTL mapping in circulating immune cells reveals genetic regulation of response-associated networks in lung cancer immunotherapy

Hyungtai Sim , Geun-Ho Park , Woong-Yang Park , Se-Hoon Lee , Murim Choi

Cancer Communications ›› 2025, Vol. 45 ›› Issue (9) : 1123 -1127.

PDF
Cancer Communications ›› 2025, Vol. 45 ›› Issue (9) : 1123 -1127. DOI: 10.1002/cac2.70042
LETTER TO THE JOURNAL

Single-cell-eQTL mapping in circulating immune cells reveals genetic regulation of response-associated networks in lung cancer immunotherapy

Author information +
History +
PDF

Cite this article

Download citation ▾
Hyungtai Sim, Geun-Ho Park, Woong-Yang Park, Se-Hoon Lee, Murim Choi. Single-cell-eQTL mapping in circulating immune cells reveals genetic regulation of response-associated networks in lung cancer immunotherapy. Cancer Communications, 2025, 45(9): 1123-1127 DOI:10.1002/cac2.70042

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Mazieres J, Drilon A, Lusque A, Mhanna L, Cortot AB, Mezquita L, et al. Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry. Ann Oncol. 2019; 30(8): 1321–8.

[2]

Hiam-Galvez KJ, Allen BM, Spitzer MH. Systemic immunity in cancer. Nat Rev Cancer. 2021; 21(6): 345–59.

[3]

van der Wijst MGP, Brugge H, de Vries DH, Deelen P, Swertz MA, LifeLines Cohort S, et al. Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs. Nat Genet. 2018; 50(4): 493–7.

[4]

Yazar S, Alquicira-Hernandez J, Wing K, Senabouth A, Gordon MG, Andersen S, et al. Single-cell eQTL mapping identifies cell type-specific genetic control of autoimmune disease. Science. 2022; 376(6589): eabf3041.

[5]

Urbut SM, Wang G, Carbonetto P, Stephens M. Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions. Nat Genet. 2019; 51(1): 187–95.

[6]

Morabito S, Reese F, Rahimzadeh N, Miyoshi E, Swarup V. hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data. Cell Rep Methods. 2023; 3(6): 100498.

[7]

Van de Sande B, Flerin C, Davie K, De Waegeneer M, Hulselmans G, Aibar S, et al. A scalable SCENIC workflow for single-cell gene regulatory network analysis. Nat Protoc. 2020; 15(7): 2247–76.

[8]

Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nat Immunol. 2005; 6(12): 1236–44.

[9]

Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, et al. The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res. 2023; 51(D1): D638–D46.

[10]

Kim N, Park S, Jo A, Eum HH, Kim HK, Lee K, et al. Unveiling the influence of tumor and immune signatures on immune checkpoint therapy in advanced lung cancer. Elife. 2024; 13: RP98366.

RIGHTS & PERMISSIONS

2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.

AI Summary AI Mindmap
PDF

37

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/