Evaluation of exposure-response-safety relationship of model-informed low-dose 500 mg abiraterone acetate in prostate cancer patients

Edmund Chiong , Ziteng Wang , Eleanor Jing Yi Cheong , Yi Chen Yao , Sin Mun Tham , Revathi Periaswami , Poh Choo Toh , Ziting Wang , Qing Hui Wu , Woon Chau Tsang , Arshvin Kesavan , Alvin Seng Cheong Wong , Patrick Thomas Wong , Felicia Lim , Shuaibing Liu , Eric Chun Yong Chan

Cancer Communications ›› 2025, Vol. 45 ›› Issue (8) : 971 -975.

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Cancer Communications ›› 2025, Vol. 45 ›› Issue (8) : 971 -975. DOI: 10.1002/cac2.70035
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Evaluation of exposure-response-safety relationship of model-informed low-dose 500 mg abiraterone acetate in prostate cancer patients

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Edmund Chiong, Ziteng Wang, Eleanor Jing Yi Cheong, Yi Chen Yao, Sin Mun Tham, Revathi Periaswami, Poh Choo Toh, Ziting Wang, Qing Hui Wu, Woon Chau Tsang, Arshvin Kesavan, Alvin Seng Cheong Wong, Patrick Thomas Wong, Felicia Lim, Shuaibing Liu, Eric Chun Yong Chan. Evaluation of exposure-response-safety relationship of model-informed low-dose 500 mg abiraterone acetate in prostate cancer patients. Cancer Communications, 2025, 45(8): 971-975 DOI:10.1002/cac2.70035

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Attard G, Reid AH, Yap TA, Raynaud F, Dowsett M, Settatree S, et al. Phase I clinical trial of a selective inhibitor of CYP17, abiraterone acetate, confirms that castration-resistant prostate cancer commonly remains hormone driven. J Clin Oncol. 2008; 26(28): 4563-71.

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Ryan CJ, Smith MR, Fong L, Rosenberg JE, Kantoff P, Raynaud F, et al. Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. J Clin Oncol. 2010; 28(9): 1481-8.

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2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat-sen University Cancer Center.

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