Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

Monika Raab , Balázs Győrffy , Samuel Peña-Llopis , Daniela Fietz , Monika Kressin , Margareta Kolaric , Matthias Ebert , Khayal Gasimli , Sven Becker , Mourad Sanhaji , Klaus Strebhardt

Cancer Communications ›› 2025, Vol. 45 ›› Issue (8) : 966 -970.

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Cancer Communications ›› 2025, Vol. 45 ›› Issue (8) : 966 -970. DOI: 10.1002/cac2.70029
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Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models

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Monika Raab, Balázs Győrffy, Samuel Peña-Llopis, Daniela Fietz, Monika Kressin, Margareta Kolaric, Matthias Ebert, Khayal Gasimli, Sven Becker, Mourad Sanhaji, Klaus Strebhardt. Targeted reactivation of the novel tumor suppressor DAPK1, an upstream regulator of p53, in high-grade serous ovarian cancer by mRNA liposomes reduces viability and enhances drug sensitivity in preclinical models. Cancer Communications, 2025, 45(8): 966-970 DOI:10.1002/cac2.70029

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Raab M, Kostova I, Peña-Llopis S, Fietz D, Kressin M, Aberoumandi SM, et al. Rescue of p53 functions by in vitro-transcribed mRNA impedes the growth of high-grade serous ovarian cancer. Cancer Commun (Lond). 2024; 44(1): 101–26.

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2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat-sen University Cancer Center.

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