Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

Lea Järke; Saskia Weber-Stiehl; Kensuke Shima; Karlis Arturs Moors; Jerome Genth; Fenja Amrei Schuran; Lena Best; Markus Tschurtschenthaler; Burkhardt Flemer; Silke Lüschen; Christoph Röcken; Andreas Tholey; Christoph Kaleta; Jan Rupp; Philip Rosenstiel; Felix Sommer

doi:10.1002/cac2.70022

Cancer Communications ›› 2025, Vol. 45 ›› Issue (7) : 722 -727. DOI: 10.1002/cac2.70022

LETTER TO THE JOURNAL

Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis

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¹. Institute of Clinical Molecular Biology, Kiel University, Kiel, Germany

². Institute of Medical Microbiology, University of Lübeck, Lübeck, Germany

³. Institute of Experimental Medicine, Kiel University, Kiel, Germany

⁴. Translational Cancer Research and Institute of Experimental Cancer Therapy, Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany

⁵. Center for Translational Cancer Research (TranslaTUM), Klinikum rechts der Isar, School of Medicine and Health, Technical University of Munich, Munich, Germany

⁶. Division of Translational Cancer Research, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany

⁷. Department of Pathology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

⁸. Infectious Disease Clinic, University Hospital Schleswig-Holstein/Campus Lübeck, Lübeck, Germany

⁹. German Center for Infection Research (DZIF), Partner Site Hamburg-Lübeck-Borstel-Riems, Lübeck, Germany

f.sommer@ikmb.uni-kiel.de

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Lea Järke, Saskia Weber-Stiehl, Kensuke Shima, Karlis Arturs Moors, Jerome Genth, Fenja Amrei Schuran, Lena Best, Markus Tschurtschenthaler, Burkhardt Flemer, Silke Lüschen, Christoph Röcken, Andreas Tholey, Christoph Kaleta, Jan Rupp, Philip Rosenstiel, Felix Sommer. Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis. Cancer Communications, 2025, 45(7): 722-727 DOI:10.1002/cac2.70022

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