Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

Ashley V. Makela , Anthony Tundo , Huiping Liu , Doug Schneider , Terry Hermiston , Pavlo Khodakivskyi , Elena Goun , Christopher H. Contag

Cancer Communications ›› 2025, Vol. 45 ›› Issue (6) : 714 -718.

PDF
Cancer Communications ›› 2025, Vol. 45 ›› Issue (6) : 714 -718. DOI: 10.1002/cac2.70018
LETTER TO THE JOURNAL

Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells

Author information +
History +
PDF

Cite this article

Download citation ▾
Ashley V. Makela, Anthony Tundo, Huiping Liu, Doug Schneider, Terry Hermiston, Pavlo Khodakivskyi, Elena Goun, Christopher H. Contag. Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells. Cancer Communications, 2025, 45(6): 714-718 DOI:10.1002/cac2.70018

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J, et al. Targeting cancer stem cell pathways for cancer therapy. Signal Transduction and Targeted Therapy. 2020; 5(1): 8.

[2]

Shiozawa Y, Nie B, Pienta KJ, Morgan TM, Taichman RS. Cancer stem cells and their role in metastasis. Pharmacol Ther. 2013; 138(2): 285-93.

[3]

Hankins HM, Baldridge RD, Xu P, Graham TR. Role of flippases, scramblases and transfer proteins in phosphatidylserine subcellular distribution. Traffic. 2015; 16(1): 35-47.

[4]

Hardy J, Bauzon M, Chan CKF, Makela AV, Kanada M, Schneider D, et al. Gla-domain mediated targeting of externalized phosphatidylserine for intracellular delivery. FASEB J. 2023; 37(8): e23113.

[5]

Guillen KP, Ruben EA, Virani N, Harrison RG. Annexin-directed β-glucuronidase for the targeted treatment of solid tumors. Protein Engineering, Design and Selection. 2017; 30(2): 85-94.

[6]

Gerber DE, Hao G, Watkins L, Stafford JH, Anderson J, Holbein B, et al. Tumor-specific targeting by Bavituximab, a phosphatidylserine-targeting monoclonal antibody with vascular targeting and immune modulating properties, in lung cancer xenografts. Am J Nucl Med Mol Imaging. 2015; 5(5): 493-503.

[7]

Liu H, Patel MR, Prescher JA, Patsialou A, Qian D, Lin J, et al. Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci USA. 2010; 107(42): 18115-20.

[8]

McKeown SR. Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response. Br J Radiol. 2014; 87(1035): 20130676.

[9]

Tsai C-F, Zhang P, Scholten D, Martin K, Wang Y-T, Zhao R, et al. Surfactant-assisted one-pot sample preparation for label-free single-cell proteomics. Commun Biol. 2021; 4(1): 265.

[10]

Li Q, Rycaj K, Chen X, Tang DG. Cancer stem cells and cell size: A causal link? Semin Cancer Biol. 2015; 35: 191-9.

RIGHTS & PERMISSIONS

2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.

AI Summary AI Mindmap
PDF

21

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/