Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors

Hye Jung Baek; Geun Hee Han; Eun Joo Cho; Jihao Xu; Min Kyung Ki; Eun Jung Park; Tae Hyun Kim; Dong Hoon Shin; Heesun Cheong; Chu-Xia Deng; Sung Chul Lim; Chang-il Hwang; Daehee Hwang; Sang Soo Kim

doi:10.1002/cac2.12663

Cancer Communications ›› 2025, Vol. 45 ›› Issue (4) : 476 -485. DOI: 10.1002/cac2.12663

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Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors

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Hye Jung Baek, Geun Hee Han, Eun Joo Cho, Jihao Xu, Min Kyung Ki, Eun Jung Park, Tae Hyun Kim, Dong Hoon Shin, Heesun Cheong, Chu-Xia Deng, Sung Chul Lim, Chang-il Hwang, Daehee Hwang, Sang Soo Kim. Inhibition of mTOR attenuates the initiation and progression of BRCA1-associated mammary tumors. Cancer Communications, 2025, 45(4): 476-485 DOI:10.1002/cac2.12663

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References

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[1]	Venkitaraman R. Triple-negative/basal-like breast cancer: clinical, pathologic and molecular features. Expert Rev Anticancer Ther. 2010; 10(2): 199–207.

[2]	Nanda R. “Targeting” triple-negative breast cancer: the lessons learned from BRCA1-associated breast cancers. Semin Oncol. 2011; 38(2): 254–262.

[3]	Chen S, Parmigiani G. Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol. 2007; 25(11): 1329–1333.

[4]	Baek HJ, Kim SE, Kim JK, Shin DH, Kim TH, Kim KG, et al. Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors. Int J Biol Sci. 2018; 14(13): 1769–1781.

[5]	Zou Z, Tao T, Li H, Zhu X. mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges. Cell Biosci. 2020; 10: 31.

[6]	Xu X, Wagner KU, Larson D, Weaver Z, Li C, Ried T, et al. Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Nat Genet. 1999; 22(1): 37–43.

[7]	Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, et al. Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997; 25(21): 4323–4330.

[8]	Risson V, Mazelin L, Roceri M, Sanchez H, Moncollin V, Corneloup C, et al. Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy. J Cell Biol. 2009; 187(6): 859–874.

[9]	Baek HJ, Kim SE, Choi EK, Kim JK, Shin DH, Park EJ, et al. Inhibition of Estrogen Signaling Reduces the Incidence of BRCA1-associated Mammary Tumor Formation. Int J Biol Sci. 2018; 14(12): 1755–1768.

[10]	Vizcaíno JA, Deutsch EW, Wang R, Csordas A, Reisinger F, Ríos D, et al. ProteomeXchange provides globally coordinated proteomics data submission and dissemination. Nat Biotechnol. 2014; 32(3): 223–226.