Single-cell multi-omics reveals tumor microenvironment factors underlying poor immunotherapy responses in ALK-positive lung cancer

Seungbyn Baek , Euijeong Sung , Gamin Kim , Min Hee Hong , Chang Young Lee , Hyo Sup Shim , Seong Yong Park , Hye Ryun Kim , Insuk Lee

Cancer Communications ›› 2025, Vol. 45 ›› Issue (4) : 422 -427.

PDF
Cancer Communications ›› 2025, Vol. 45 ›› Issue (4) : 422 -427. DOI: 10.1002/cac2.12658
LETTER TO THE JOURNAL

Single-cell multi-omics reveals tumor microenvironment factors underlying poor immunotherapy responses in ALK-positive lung cancer

Author information +
History +
PDF

Cite this article

Download citation ▾
Seungbyn Baek, Euijeong Sung, Gamin Kim, Min Hee Hong, Chang Young Lee, Hyo Sup Shim, Seong Yong Park, Hye Ryun Kim, Insuk Lee. Single-cell multi-omics reveals tumor microenvironment factors underlying poor immunotherapy responses in ALK-positive lung cancer. Cancer Communications, 2025, 45(4): 422-427 DOI:10.1002/cac2.12658

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Schenk EL. Narrative review: immunotherapy in anaplastic lymphoma kinase (ALK)+ lung cancer—current status and future directions. Transl Lung Cancer Res. 2023; 12(2): 322.

[2]

Fares J, Fares MY, Khachfe HH, Salhab HA, Fares Y. Molecular principles of metastasis: a hallmark of cancer revisited. Signal Transduct Target Ther. 2020; 5(1): 28.

[3]

Network CGAR. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014; 511(7511): 543.

[4]

Chang RB, Beatty GL. The interplay between innate and adaptive immunity in cancer shapes the productivity of cancer immunosurveillance. J Leukoc Biol. 2020; 108(1): 363-376.

[5]

Waters LR, Ahsan FM, Wolf DM, Shirihai O, Teitell MA. Initial B cell activation induces metabolic reprogramming and mitochondrial remodeling. iScience. 2018; 5: 99-109.

[6]

Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020; 577(7791): 549-555.

[7]

Kim T-S, Shin E-C. The activation of bystander CD8+ T cells and their roles in viral infection. Exp Mol Med. 2019; 51(12): 1-9.

[8]

Kurachi M, Barnitz RA, Yosef N, Odorizzi PM, DiIorio MA, Lemieux ME, et al. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol. 2014; 15(4): 373-383.

[9]

Seo H, González-Avalos E, Zhang W, Ramchandani P, Yang C, Lio C-WJ, et al. BATF and IRF4 cooperate to counter exhaustion in tumor-infiltrating CAR T cells. Nat Immunol. 2021; 22(8): 983-995.

[10]

Taveirne S, Wahlen S, Van Loocke W, Kiekens L, Persyn E, Van Ammel E, et al. The transcription factor ETS1 is an important regulator of human NK cell development and terminal differentiation. Blood. 2020; 136(3): 288-298.

RIGHTS & PERMISSIONS

2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.

AI Summary AI Mindmap
PDF

18

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/