Cytotoxic and regulatory T cell interactions calculated from image mass cytometry predict immunochemotherapy response in triple-negative breast cancer

Xiang Wang , Jing Dong , Jian-Rong Li , Yupei Lin , Bikram Sahoo , Yong Li , Yanhong Liu , Robert Taylor Ripley , Jia Wu , Jianjun Zhang , Christopher I Amos , Chao Cheng

Cancer Communications ›› 2025, Vol. 45 ›› Issue (4) : 392 -396.

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Cancer Communications ›› 2025, Vol. 45 ›› Issue (4) : 392 -396. DOI: 10.1002/cac2.12652
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Cytotoxic and regulatory T cell interactions calculated from image mass cytometry predict immunochemotherapy response in triple-negative breast cancer

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Xiang Wang, Jing Dong, Jian-Rong Li, Yupei Lin, Bikram Sahoo, Yong Li, Yanhong Liu, Robert Taylor Ripley, Jia Wu, Jianjun Zhang, Christopher I Amos, Chao Cheng. Cytotoxic and regulatory T cell interactions calculated from image mass cytometry predict immunochemotherapy response in triple-negative breast cancer. Cancer Communications, 2025, 45(4): 392-396 DOI:10.1002/cac2.12652

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References

[1]

Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, et al. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine. 2018; 24(5): 541-550.

[2]

Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020; 577(7791): 549-555.

[3]

Loi S, Michiels S, Salgado R, Sirtaine N, Jose V, Fumagalli D, et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: results from the FinHER trial. Annals of Oncology. 2014; 25(8): 1544-1550.

[4]

Qian Wang X, Danenberg E, Huang C-S, Egle D, Callari M, Bermejo B, et al. Spatial predictors of immunotherapy response in triple-negative breast cancer. Pinuccia Valagussa. 2023; 621: 868.

[5]

Windhager J, Zanotelli VRT, Schulz D, Meyer L, Daniel M, Bodenmiller B, et al. An end-to-end workflow for multiplexed image processing and analysis. Nature Protocols. 2023; 18(11): 3565-3613.

[6]

Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, et al. Granzyme B regulates antiviral CD8+ T cell responses. Journal of immunology (Baltimore, Md: 1950). 2011; 187(12): 6301-6309.

[7]

Li J, Zhang H, Wu J, Li L, Xu B, Song Q. Granzymes expression patterns predict immunotherapy response and identify the heterogeneity of CD8+ T cell subsets. Cancer Biomarkers. 2023; 38(1): 77-102.

[8]

Hwang HK, Kim HI, Kim SH, Choi J, Kang CM, Kim KS, et al. Prognostic impact of the tumor-infiltrating regulatory T-cell (Foxp3(+))/activated cytotoxic T lymphocyte (granzyme B(+)) ratio on resected left-sided pancreatic cancer. Oncol Lett. 2016; 12(6): 4477-4484.

[9]

Kumagai S, Togashi Y, Kamada T, Sugiyama E, Nishinakamura H, Takeuchi Y, et al. The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies. Nature Immunology. 2020; 21(11): 1346-1358.

[10]

Kamada T, Togashi Y, Tay C, Ha D, Sasaki A, Nakamura Y, et al. PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. Proceedings of the National Academy of Sciences of the United States of America. 2019; 116(20): 9999-10008.

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2025 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.

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