Vascular smooth muscle cell plasticity in the tumor microenvironment

Caitlin F. Bell, Richard A. Baylis, Nicolas G. Lopez, Wei Feng Ma, Hua Gao, Fudi Wang, Sharika Bamezai, Changhao Fu, Yoko Kojima, Shaunak S. Adkar, Lingfeng Luo, Clint L. Miller, Nicholas J. Leeper

Cancer Communications ›› 2025, Vol. 45 ›› Issue (02) : 167-171.

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Cancer Communications ›› 2025, Vol. 45 ›› Issue (02) : 167-171. DOI: 10.1002/cac2.12635
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Vascular smooth muscle cell plasticity in the tumor microenvironment

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Caitlin F. Bell, Richard A. Baylis, Nicolas G. Lopez, Wei Feng Ma, Hua Gao, Fudi Wang, Sharika Bamezai, Changhao Fu, Yoko Kojima, Shaunak S. Adkar, Lingfeng Luo, Clint L. Miller, Nicholas J. Leeper. Vascular smooth muscle cell plasticity in the tumor microenvironment. Cancer Communications, 2025, 45(02): 167‒171 https://doi.org/10.1002/cac2.12635

References

[1]
Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, et al. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med. 2016; 22(6): 657-65.
CrossRef Google scholar
[2]
Rong JX, Shapiro M, Trogan E, Fisher EA. Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading. Proc Natl Acad Sci U S A. 2003; 100(23): 13531-6.
CrossRef Google scholar
[3]
Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K. Schaller M, et al. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res. 2014; 115(7): 662-7.
CrossRef Google scholar
[4]
Alencar GF, Owsiany KM, Karnewar S, Sukhavasi K, Mocci G, Nguyen AT, et al. Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis. Circulation. 2020; 142(21): 2045-59.
CrossRef Google scholar
[5]
Wang Y, Nanda V, Direnzo D, Ye J, Xiao S, Kojima Y, et al. Clonally expanding smooth muscle cells promote atherosclerosis by escaping efferocytosis and activating the complement cascade. Proc Natl Acad Sci U S A. 2020; 117(27): 15818-26.
CrossRef Google scholar
[6]
Mahauad-Fernandez WD, Naushad W, Panzner TD, Bashir A, Lal G, Okeoma CM. BST-2 promotes survival in circulation and pulmonary metastatic seeding of breast cancer cells. Sci Rep. 2018; 8(1): 17608.
CrossRef Google scholar
[7]
Mukai S, Oue N, Oshima T, Mukai R, Tatsumoto Y, Sakamoto N, et al. Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer. Ann Surg Oncol. 2017; 24(2): 594-602.
CrossRef Google scholar
[8]
Ma G, Pan PY, Eisenstein S, Divino CM, Lowell CA, Takai T, et al. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells. Immunity. 2011; 34(3): 385-95.
CrossRef Google scholar
[9]
Luo L, Fu C, Bell CF, Wang Y, Leeper NJ. Role of vascular smooth muscle cell clonality in atherosclerosis. Front Cardiovasc Med. 2023; 10: 1273596.
CrossRef Google scholar
[10]
Hosaka K, Yang Y, Seki T, Fischer C, Dubey O, Fredlund E, et al. Pericyte-fibroblast transition promotes tumor growth and metastasis. Proc Natl Acad Sci U S A. 2016; 113(38): E5618-27.
CrossRef Google scholar

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2024 2024 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd. on behalf of Sun Yat-sen University Cancer Center.
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