PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer

Abul Azad; Maryam Arshad; Daniele Generali; Katharina Feldinger; Merel Gijsen; Carla Strina; Mariarosa Cappelletti; Daniele Andreis; Russell Leek; Syed Haider; Pirkko-Liisa Kellokumpu-Lehtinen; Ioannis Roxanis; Adrian Llewellyn Harris; Abeer Mahmoud Shaaban; Heikki Joensuu; Anthony Kong

doi:10.1002/cac2.12632

Cancer Communications ›› 2025, Vol. 45 ›› Issue (01) : 68 -73. DOI: 10.1002/cac2.12632

LETTER TO THE JOURNAL

PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer

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¹. Department of Oncology, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK

². Institute of Genomic and Cancer Sciences, Vincent Drive, University of Birmingham, Birmingham, UK

³. Comprehensive Cancer Centre, Kings’ College London, London, UK

⁴. U.O. Multidisciplinare di Patologia Mammaria, U.S Terapia Molecolare e Farmacogenomica, A.O. Instituti Ospitalieri di Cremona, Viale Concordia 1, Cremona, Italy

⁵. Biostatistics and Clinical Trials Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori IRCCS, Forlì-Cesena, Meldola, Italy

⁶. The Institute of Cancer Research, London, UK

⁷. Department of Oncology, Tampere University Hospital and Tampere University, Tampere, Finland

⁸. Department of Cellular Pathology, Oxford University Hospitals and Oxford Biomedical Research Centre, Oxford, UK

⁹. Department of histopathology, Queen Elizabeth Hospital Birmingham, Birmingham, UK

¹⁰. Department of Oncology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland

anthony.kong@kcl.ac.uk

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Abul Azad, Maryam Arshad, Daniele Generali, Katharina Feldinger, Merel Gijsen, Carla Strina, Mariarosa Cappelletti, Daniele Andreis, Russell Leek, Syed Haider, Pirkko-Liisa Kellokumpu-Lehtinen, Ioannis Roxanis, Adrian Llewellyn Harris, Abeer Mahmoud Shaaban, Heikki Joensuu, Anthony Kong. PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer. Cancer Communications, 2025, 45(01): 68-73 DOI:10.1002/cac2.12632

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References

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