Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy

Sung-Woo Lee; Young Ju Kim; Saei Jeong; Kyung Na Rho; Jeong Eun Noh; Hee-Ok Kim; Hyun-Ju Cho; Yoo Duk Choi; Deok Hwan Yang; Eu Chang Hwang; Woo Kyun Bae; Sook Jung Yun; Ju Sik Yun; Cheol-Kyu Park; In-Jae Oh; Jae-Ho Cho

doi:10.1002/cac2.12631

Cancer Communications ›› 2025, Vol. 45 ›› Issue (01) : 58 -62. DOI: 10.1002/cac2.12631

LETTER TO THE JOURNAL

Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy

Sung-Woo Lee ¹^,²^,³^,^†
, Young Ju Kim ¹^,²^,³^,⁴
, Saei Jeong ¹^,²^,³^,⁴
, Kyung Na Rho ¹^,²^,³^,⁴
, Jeong Eun Noh ¹^,²^,³^,⁴
, Hee-Ok Kim ⁵
, Hyun-Ju Cho ⁶
, Yoo Duk Choi ⁷
, Deok Hwan Yang ⁶
, Eu Chang Hwang ⁸
, Woo Kyun Bae ⁶
, Sook Jung Yun ⁹
, Ju Sik Yun ¹⁰
, Cheol-Kyu Park ⁶
, In-Jae Oh ⁶^,^†
, Jae-Ho Cho ¹^,²^,³^,⁴^,^†

Author information +

¹. Department of Microbiology and Immunology, Chonnam National University Medical School, Hwasunup, Jeollanamdo, Republic of Korea

². Medical Research Center for Combinatorial Tumor Immunotherapy, Chonnam National University Medical School, Hwasunup, Jeollanamdo, Republic of Korea

³. National Immunotherapy Innovation Center, Chonnam National University Medical School, Hwasunup, Jeollanamdo, Republic of Korea

⁴. Bio Medical Sciences Graduate Program, Chonnam National University Medical School, Hwasunup, Jeollanamdo, Republic of Korea

⁵. Selecxine Inc., Seoul, Republic of Korea

⁶. Department of Internal Medicine, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea

⁷. Department of Pathology, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea

⁸. Department of Urology, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea

⁹. Department of Dermatology, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea

¹⁰. Department of Thoracic and Cardiovascular Surgery, Chonnam National University Medical School, Hwasun Hospital, Hwasunup, Jeollanamdo, Republic of Korea

swl526@jnu.ac.kr

droij@jnu.ac.kr

jh_cho@jnu.ac.kr

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Sung-Woo Lee, Young Ju Kim, Saei Jeong, Kyung Na Rho, Jeong Eun Noh, Hee-Ok Kim, Hyun-Ju Cho, Yoo Duk Choi, Deok Hwan Yang, Eu Chang Hwang, Woo Kyun Bae, Sook Jung Yun, Ju Sik Yun, Cheol-Kyu Park, In-Jae Oh, Jae-Ho Cho. Ex vivo STAT3 phosphorylation in circulating immune cells: a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy. Cancer Communications, 2025, 45(01): 58-62 DOI:10.1002/cac2.12631

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