Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon

Sheema Almozyan; Roya Babaei-Jadidi; Abrar Aljohani; Sepideh Youssefi; William Dalleywater; Prerna Kadam; Bradley Spencer-Dene; Emad Rakha; Mohammad Ilyas; Abdolrahman Shams Nateri

doi:10.1002/cac2.12625

Cancer Communications ›› 2025, Vol. 45 ›› Issue (01) : 9 -14. DOI: 10.1002/cac2.12625

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Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon

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¹. Cancer Genetics & Stem Cell Group, BioDiscovery Institute, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK

². Department of Cell Therapy and Immunobiology, Research & Innovation Centre, King Faisal Specialist Hospital & Research Centre, RUH, Riyadh, Saudi Arabia

³. Respiratory Medicine, BioDiscovery Institute, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK

⁴. University of Nottingham and Nottingham University City Hospital, School of Medicine, Nottingham, Nottinghamshire, UK

⁵. Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia

⁶. Histopathology, Queens Medical Centre, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK

⁷. Experimental Histopathology, The Francis Crick Institute, London, UK

⁸. Non-Clinical Histology, Bioimaging, GSK, Stevenage, Hertfordshire, UK

⁹. Academic Unit of Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, Nottinghamshire, UK

a.nateri@nottingham.ac.uk

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Sheema Almozyan, Roya Babaei-Jadidi, Abrar Aljohani, Sepideh Youssefi, William Dalleywater, Prerna Kadam, Bradley Spencer-Dene, Emad Rakha, Mohammad Ilyas, Abdolrahman Shams Nateri. Wnt/GSK-3β mediates posttranslational modifications of FLYWCH1 to regulate intestinal epithelial function and tumorigenesis in the colon. Cancer Communications, 2025, 45(01): 9-14 DOI:10.1002/cac2.12625

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References

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