IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells

Soojeong Noh, Suyeon Ryu, Dokyung Jung, Sanghee Shin, Inseong Jung, Sung-Min Kang, Christine Seulki Kim, Sung-Jin Choi, Hanchae Cho, Melanie Schwämmle, Youngtae Jeong, Felicitas Bucher, Il-Kyu Choi, Shin Yup Lee, Sin-Hyeog Im, Kyungmoo Yea, Moon-Chang Baek

Cancer Communications ›› 2024, Vol. 44 ›› Issue (12) : 1422-1426.

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Cancer Communications ›› 2024, Vol. 44 ›› Issue (12) : 1422-1426. DOI: 10.1002/cac2.12623
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IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells

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Soojeong Noh, Suyeon Ryu, Dokyung Jung, Sanghee Shin, Inseong Jung, Sung-Min Kang, Christine Seulki Kim, Sung-Jin Choi, Hanchae Cho, Melanie Schwämmle, Youngtae Jeong, Felicitas Bucher, Il-Kyu Choi, Shin Yup Lee, Sin-Hyeog Im, Kyungmoo Yea, Moon-Chang Baek. IL2-mediated modulation of small extracellular vesicles secretion and PD-L1 expression: a novel perspective for neutralizing immune suppression within cancer cells. Cancer Communications, 2024, 44(12): 1422‒1426 https://doi.org/10.1002/cac2.12623

References

[1]
Becker A, Thakur BK, Weiss JM, Kim HS, Peinado H, Lyden D. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. Cancer Cell. 2016; 30: 836-48.
CrossRef Google scholar
[2]
Gong L, Yan Q, Zhang Y, Fang X, Liu B, Guan X. Cancer cell reprogramming: a promising therapy converting malignancy to benignity. Cancer Commun. 2019; 39: 48.
CrossRef Google scholar
[3]
Blank C, Gajewski TF, Mackensen A. Interaction of PD-L1 on tumor cells with PD-1 on tumor-specific T cells as a mechanism of immune evasion: implications for tumor immunotherapy. Cancer Immunol Immunother. 2005; 54: 307-14.
CrossRef Google scholar
[4]
Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, et al. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018; 560: 382-6.
CrossRef Google scholar
[5]
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012; 12: 252-64.
CrossRef Google scholar
[6]
Malek TR, Castro I. Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity. Immunity. 2010; 33: 153-65.
CrossRef Google scholar
[7]
Nakamura Y, Russell SM, Mess SA, Friedmann M, Erdos M, Francois C, et al. Heterodimerization of the IL-2 receptor β-and γ-chain cytoplasmic domains is required for signalling. Nature. 1994; 369: 330-3.
CrossRef Google scholar
[8]
Ross SH, Cantrell DA. Signaling and Function of Interleukin-2 in T Lymphocytes. Annu Rev Immunol. 2018; 36: 411-33.
CrossRef Google scholar
[9]
Shin S, Jung I, Jung D, Kim CS, Kang SM, Ryu S, et al. Novel antitumor therapeutic strategy using CD4+ T cell-derived extracellular vesicles. Biomaterials. 2022; 289: 121765.
CrossRef Google scholar
[10]
Zha Z, Bucher F, Nejatfard A, Zheng T, Zhang H, Yea K, et al. Interferon-γ is a master checkpoint regulator of cytokine-induced differentiation. Proc Natl Acad Sci U S A. 2017; 114: 6867-74.
CrossRef Google scholar

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2024 2024 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat-sen University Cancer Center.
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