
Engineering heavy chain antibody-drug conjugates against solid tumors for a one-shot kill
Xue Liu, Wenjing Ning, Lei Wang, Han Liu, Hongye Zeng, Xiaojing Qin, Yuanzhi Chen, Fentian Chen, Lin Xu, Yang Zhao, Xiaoqing Chen, Jixian Tang, Yunlong Ren, Xiaowen Yan, Wenxin Luo, Ningshao Xia
Cancer Communications ›› 2024, Vol. 44 ›› Issue (12) : 1444-1448.
Engineering heavy chain antibody-drug conjugates against solid tumors for a one-shot kill
[1] |
Dumontet C, Reichert JM, Senter PD, Lambert JM, Beck A. Antibody-drug conjugates come of age in oncology. Nat Rev Drug Discov. 2023; 22(8): 641–661.
CrossRef
Google scholar
|
[2] |
Tarantino P, Ricciuti B, Pradhan SM, Tolaney SM. Optimizing the safety of antibody-drug conjugates for patients with solid tumours. Nat Rev Clin Oncol. 2023; 20(8): 558–576.
CrossRef
Google scholar
|
[3] |
Passaro A, Jänne PA, Peters S. Antibody-Drug Conjugates in Lung Cancer: Recent Advances and Implementing Strategies. J Clin Oncol. 2023; 41(21): 3747–3761.
CrossRef
Google scholar
|
[4] |
Tsuchikama K, Anami Y, Ha SYY, Yamazaki CM. Exploring the next generation of antibody-drug conjugates. Nat Rev Clin Oncol. 2024; 21(3): 203–223.
CrossRef
Google scholar
|
[5] |
Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer. 2006; 6(8): 583–592.
CrossRef
Google scholar
|
[6] |
Strack R. Nanobodies made versatile. Nat Methods. 2023; 20(1): 37.
CrossRef
Google scholar
|
[7] |
Muyldermans S. Nanobodies: natural single-domain antibodies. Annu Rev Biochem. 2013; 82: 775–797.
CrossRef
Google scholar
|
[8] |
Wu Y, Li Q, Kong Y, Wang Z, Lei C, Li j, et al. A highly stable human single-domain antibody-drug conjugate exhibits superior penetration and treatment of solid tumors. Mol Ther. 2022; 30(8): 2785–2799.
CrossRef
Google scholar
|
[9] |
Gan X, Shan Q, Li H, Janssens R, Shen Y, He Y, et al. An anti-CTLA-4 heavy chain-only antibody with enhanced Treg depletion shows excellent preclinical efficacy and safety profile. Proc Natl Acad Sci U S A. 2022; 119(32): e2200879119.
CrossRef
Google scholar
|
[10] |
Xu C, Zhu M, Wang Q, Cui J, Huang Y, Huang X, et al. TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer. J Nanobiotechnology. 2023; 21(1): 410.
CrossRef
Google scholar
|
/
〈 |
|
〉 |