Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling

Suguru Saito, Duo-Yao Cao, Tomohiro Shibata, Yan Liu, Aoi Otagiri-Hoshi, Xiaojiang Cui, Kenneth E. Bernstein

Cancer Communications ›› 2025, Vol. 45 ›› Issue (01) : 4-8.

PDF
Cancer Communications ›› 2025, Vol. 45 ›› Issue (01) : 4-8. DOI: 10.1002/cac2.12615
LETTER TO THE JOURNAL

Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling

Author information +
History +

Cite this article

Download citation ▾
Suguru Saito, Duo-Yao Cao, Tomohiro Shibata, Yan Liu, Aoi Otagiri-Hoshi, Xiaojiang Cui, Kenneth E. Bernstein. Tumor derived cell-free nucleic acid upregulates programmed death-ligand 1 expression in neutrophil via intracellular Toll-like receptor signaling. Cancer Communications, 2025, 45(01): 4‒8 https://doi.org/10.1002/cac2.12615

References

[1]
Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018; 18(2): 134-147.
CrossRef Google scholar
[2]
Döring Y, Drechsler M, Soehnlein O, Weber C. Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 2015; 35(2): 288-295.
CrossRef Google scholar
[3]
Hedrick CC, Malanchi I. Neutrophils in cancer: heterogeneous and multifaceted. Nat Rev Immunol. 2022; 22(3): 173-187.
CrossRef Google scholar
[4]
Tang D, Zhang D, Heng Y, Zhu XK, Lin HQ, Zhou J, et al. Tumor-Infiltrating PD-L1+ Neutrophils Induced by GM-CSF Suppress T Cell Function in Laryngeal Squamous Cell Carcinoma and Predict Unfavorable Prognosis. J Inflamm Res. 2022; 15: 1079-1097.
CrossRef Google scholar
[5]
Pylaeva E, Korschunow G, Spyra I, Bordbari S, Siakaeva E, Ozel I, et al. During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes. Cell Rep. 2022; 40(7): 111171.
CrossRef Google scholar
[6]
Cheng Y, Li H, Deng Y, Tai Y, Zeng K, Zhang Y, et al. Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma. Cell Death Dis. 2018; 9(4): 422.
CrossRef Google scholar
[7]
Cisneros-Villanueva M, Hidalgo-Pérez L, Rios-Romero M. Cedro-Tanda A, Ruiz-Villavicencio CA. Page K, et al. Cell-free DNA analysis in current cancer clinical trials: a review. Br J Cancer. 2022; 126(3): 391-400.
CrossRef Google scholar
[8]
Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol. 2004; 4(7): 499-511.
CrossRef Google scholar
[9]
Sun R, Xiong Y, Liu H, Gao C, Su L, Weng J, et al. Tumor-associated neutrophils suppress antitumor immunity of NK cells through the PD-L1/PD-1 axis. Transl Oncol. 2020; 13(10): 100825.
CrossRef Google scholar
[10]
Schlee M, Hartmann G. Discriminating self from non-self in nucleic acid sensing. Nat Rev Immunol. 2016; 16(9): 566-580.
CrossRef Google scholar

RIGHTS & PERMISSIONS

2024 2024 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat-sen University Cancer Center.
PDF

Accesses

Citations

Detail

Sections
Recommended

/