
Deciphering protective genomic factors of tumor development in pediatric Down syndrome via deep learning approach to whole genome and RNA sequencing
Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D Mentch, Haijun Qiu, Kenny Nguyen, Kayleigh Ostberg, Tiancheng Wang, Joseph Glessner, Hakon Hakonarson
Cancer Communications ›› 2024, Vol. 44 ›› Issue (11) : 1374-1378.
Deciphering protective genomic factors of tumor development in pediatric Down syndrome via deep learning approach to whole genome and RNA sequencing
[1] |
Hasle H, Friedman JM, Olsen JH, Rasmussen SA. Low risk of solid tumors in persons with Down syndrome. Genet Med. 2016; 18(11): 1151-7.
CrossRef
Google scholar
|
[2] |
Osuna-Marco MP, López-Barahona M, López-Ibor B, Tejera ÁM. Ten reasons why people with down syndrome are protected from the development of most solid tumors-a review. Front Genet. 2021; 12: 749480.
CrossRef
Google scholar
|
[3] |
Satgé D, Bénard J, editors. Carcinogenesis in Down syndrome: What can be learned from trisomy 21? Semin Cancer Biol. 2008: 18(5): 365-71.
CrossRef
Google scholar
|
[4] |
Pomerantz JH, Blau HM. Tumor suppressors: enhancers or suppressors of regeneration? Development. 2013; 140(12): 2502-12.
CrossRef
Google scholar
|
[5] |
Pirozzi CJ, Yan H. The implications of IDH mutations for cancer development and therapy. Nat Rev Clin Oncol. 2021; 18(10): 645-61.
CrossRef
Google scholar
|
[6] |
Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014; 14(2): 77-91.
CrossRef
Google scholar
|
[7] |
Jantrapirom S, Lo Piccolo L, Pruksakorn D, Potikanond S, Nimlamool W. Ubiquilin networking in cancers. Cancers. 2020; 12(6): 1586.
CrossRef
Google scholar
|
[8] |
Cho J, Pastorino S, Zeng Q, Xu X, Johnson W, Vandenberg S, et al. Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer Res. 2011; 71(24): 7587-96.
CrossRef
Google scholar
|
[9] |
Zhu Y-c, Wang W-x, Li X-l. Xu C-w, Chen G, Zhuang W, et al. Identification of a novel icotinib-sensitive EGFR-SEPTIN14 fusion variant in lung adenocarcinoma by next-generation sequencing. J Thorac Oncol. 2019; 14(8): e181-e3.
CrossRef
Google scholar
|
[10] |
Sur S, Ray RB. Emerging role of lncRNA ELDR in development and cancer. FEBS J. 2022; 289(11): 3011-23.
CrossRef
Google scholar
|
/
〈 |
|
〉 |