Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation

Pengbo Yao; Gaoxiang Zhao; Min Li; Wensheng Qiu; Zhimin Lu

doi:10.1002/cac2.12599

Cancer Communications ›› 2024, Vol. 44 ›› Issue (10) : 1102 -1105. DOI: 10.1002/cac2.12599

RESEARCH HIGHLIGHTS

Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation

Pengbo Yao ¹
, Gaoxiang Zhao ¹
, Min Li ²
, Wensheng Qiu ¹^,^†
, Zhimin Lu ²^,³^,⁴^,^†

Author information +

History +

PDF

Cite this article

Download citation ▾

Pengbo Yao, Gaoxiang Zhao, Min Li, Wensheng Qiu, Zhimin Lu. Abrogation of nuclear entry of TERT by fructose 1,6-bisphosphatase 1-mediated dephosphorylation. Cancer Communications, 2024, 44(10): 1102-1105 DOI:10.1002/cac2.12599

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Sahin E, DePinho RA. Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol. 2012; 13(6): 397-404.

[2]	Jeong SA, Kim K, Lee JH, Cha JS, Khadka P, Cho HS, et al. Akt-mediated phosphorylation increases the binding affinity of hTERT for importin alpha to promote nuclear translocation. J Cell Sci. 2015; 128(12): 2287-301.

[3]	Li M, Wang Z, Tao J, Jiang H, Yang H, Guo D, et al. Fructose-1, 6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression. Nat Chem Biol. 2024.

[4]	Thompson CB, Vousden KH, Johnson RS, Koppenol WH, Sies H, Lu Z, et al. A century of the Warburg effect. Nat Metab. 2023; 5(11): 1840-3.

[5]	Xu Y, Hino C, Baylink DJ, Xiao J, Reeves ME, Zhong JF, et al. Vitamin D activates FBP1 to block the Warburg effect and modulate blast metabolism in acute myeloid leukemia. Biomark Res. 2022; 10(1): 16.

[6]	Guo D, Tong Y, Jiang X, Meng Y, Jiang H, Du L, et al. Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IkappaBalpha. Cell Metab. 2022; 34(9):1312-24 e6.

[7]	Wu K, Yan M, Liu T, Wang Z, Duan Y, Xia Y, et al. Creatine kinase B suppresses ferroptosis by phosphorylating GPX4 through a moonlighting function. Nat Cell Biol. 2023; 25(5): 714-25.

[8]	Bian X, Jiang H, Meng Y, Li YP, Fang J, Lu Z. Regulation of gene expression by glycolytic and gluconeogenic enzymes. Trends Cell Biol. 2022; 32(9): 786-99.

[9]	Wang Z, Li M, Jiang H, Luo S, Shao F, Xia Y, et al. Fructose-1, 6-bisphosphatase 1 functions as a protein phosphatase to dephosphorylate histone H3 and suppresses PPARalpha-regulated gene transcription and tumour growth. Nat Cell Biol. 2022; 24(11): 1655-65.

[10]	Zhu W, Chu H, Zhang Y, Luo T, Yu H, Zhu H, et al. Fructose-1, 6-bisphosphatase 1 dephosphorylates IkappaBalpha and suppresses colorectal tumorigenesis. Cell Res. 2023; 33(3): 245-57.