
Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
Sung Hee Choi, Jay Thomas Myers, Suzanne Louise Tomchuck, Melissa Bonner, Saada Eid, Daniel Tyler Kingsley, Kristen Ashley VanHeyst, Seong-Jin Kim, Byung-Gyu Kim, Alex Yee-Chen Huang
Cancer Communications ›› 2024, Vol. 44 ›› Issue (08) : 884-888.
Oral transforming growth factor-beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti-tumor immunity
[1] |
PetrilliAS, de Camargo B, FilhoVO, BrunieraP, Brunetto AL, Jesus-GarciaR. et al. Results of the Brazilian Osteosarcoma Treatment Group Studies III and IV: prognostic factors and impact on survival. J Clin Oncol. 2006; 24(7): 1161–1168.
CrossRef
Google scholar
|
[2] |
XuS, YangS, SunG, HuangW, ZhangY. Transforming growth factor-beta polymorphisms and serum level in the development of osteosarcoma. DNA Cell Biol. 2014; 33(11): 802–806.
CrossRef
Google scholar
|
[3] |
KimBG, MalekE, ChoiSH, Ignatz-Hoover JJ. DriscollJJ. Novel therapies emerging in oncology to target the TGF-beta pathway. J Hematol Oncol. 2021; 14(1): 55.
CrossRef
Google scholar
|
[4] |
SonJY, ParkSY, KimSJ, Lee SJ, ParkSA, KimMJ, et al. EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis. Mol Cancer Ther. 2014; 13(7): 1704–1716.
CrossRef
Google scholar
|
[5] |
de Oliveira RodriguesMT, Pereira da SilvaL, Pogue RE, de CarvalhoJL, MotoyamaAB, de Alencar EST, et al. Induced resistance to ifosfamide in osteosarcoma cells suggests a more aggressive tumor profile. Biochem Biophys Rep. 2022; 32: 101357.
CrossRef
Google scholar
|
[6] |
Garces de Los Fayos AlonsoI, LiangHC, TurnerSD, LaggerS, Merkel O, KennerL. The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas. Cancers (Basel). 2018; 10(4): 93.
CrossRef
Google scholar
|
[7] |
ChenD, ZhaoZ, HuangZ, Chen DC, ZhuXX, WangYZ, et al. Super enhancer inhibitors suppress MYC driven transcriptional amplification and tumor progression in osteosarcoma. Bone Res. 2018; 6: 11.
CrossRef
Google scholar
|
[8] |
WongDP, FritzCE, FeinbergD, Huang AY, ParameswaranR. p35 is a Crucial Player in NK-cell Cytotoxicity and TGFbeta-mediated NK-cell Dysfunction. Cancer Res Commun. 2023; 3(5): 793–806.
CrossRef
Google scholar
|
[9] |
YangH, ZhaoL, ZhangY, Li FF. A comprehensive analysis of immune infiltration in the tumor microenvironment of osteosarcoma. Cancer Med. 2021; 10(16): 5696–5711.
CrossRef
Google scholar
|
[10] |
BoyeK, LonghiA, GurenT, Lorenz S, NaessS, PieriniM, et al. Pembrolizumab in advanced osteosarcoma: results of a single-arm, open-label, phase 2 trial. Cancer Immunol Immunother. 2021; 70(9): 2617–2624.
CrossRef
Google scholar
|
/
〈 |
|
〉 |