Interleukin-10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath

Christoph Heuser-Loy

Cancer Communications ›› 2024, Vol. 44 ›› Issue (07) : 787-790.

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Cancer Communications ›› 2024, Vol. 44 ›› Issue (07) : 787-790. DOI: 10.1002/cac2.12575
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Interleukin-10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath

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Christoph Heuser-Loy. Interleukin-10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath. Cancer Communications, 2024, 44(07): 787‒790 https://doi.org/10.1002/cac2.12575

References

[1]
Labanieh L, Mackall CL. CAR immune cells: design principles, resistance and the next generation. Nature. 2023; 614(7949): 635-48.
CrossRef Google scholar
[2]
Heuser C, Renner K, Kreutz M, Gattinoni L. Targeting lactate metabolism for cancer immunotherapy -a matter of precision. Semin Cancer Biol. 2023; 88: 32-45.
CrossRef Google scholar
[3]
Reina-Campos M, Scharping NE, Goldrath AW. CD8(+) T cell metabolism in infection and cancer. Nat Rev Immunol. 2021; 21(11): 718-38.
CrossRef Google scholar
[4]
Baessler A, Vignali DAA. T Cell Exhaustion. Annu Rev Immunol. 2024.
[5]
Gebhardt T, Park SL, Parish IA. Stem-like exhausted and memory CD8(+) T cells in cancer. Nat Rev Cancer. 2023; 23(11): 780-98.
CrossRef Google scholar
[6]
Zhao Y, Chen J, Andreatta M, Feng B, Xie YQ, Wenes M, et al. IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases. Nat Biotechnol. 2024.
[7]
Salkeni MA, Naing A. Interleukin-10 in cancer immunotherapy: from bench to bedside. Trends Cancer. 2023; 9(9): 716-25.
CrossRef Google scholar
[8]
Guo Y, Xie YQ, Gao M, Zhao Y, Franco F, Wenes M, et al. Metabolic reprogramming of terminally exhausted CD8(+) T cells by IL-10 enhances anti-tumor immunity. Nat Immunol. 2021; 22(6): 746-56.
CrossRef Google scholar
[9]
Zehn D, Thimme R, Lugli E, de Almeida GP, Oxenius A. ‘Stem-like’ precursors are the fount to sustain persistent CD8(+) T cell responses. Nat Immunol. 2022; 23(6): 836-47.
CrossRef Google scholar
[10]
Hanna BS, Llao-Cid L. Iskar M, Roessner PM, Klett LC, Wong JKL, et al. Interleukin-10 receptor signaling promotes the maintenance of a PD-1(int) TCF-1(+) CD8(+) T cell population that sustains anti-tumor immunity. Immunity. 2021; 54(12): 2825-41. e10.
CrossRef Google scholar

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2024 2024 The Author(s). Cancer Communications published by John Wiley & Sons Australia, Ltd on behalf of Sun Yat-sen University Cancer Center.
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