Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

Bianca Cesaro; Alessia Iaiza; Fabio Piscopo; Marco Tarullo; Eleonora Cesari; Dante Rotili; Antonello Mai; Alberto Diana; Michela Londero; Luca Del Giacco; Riccardo Masetti; Alba Di Leone; Chiara Naro; Silvia Masciarelli; Giulia Fontemaggi; Claudio Sette; Francesco Fazi; Alessandro Fatica

doi:10.1002/cac2.12509

Cancer Communications ›› 2024, Vol. 44 ›› Issue (2) :282 -286. DOI: 10.1002/cac2.12509

LETTER TO THE EDITOR

Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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¹. Department of Anatomical, Histological, Forensic & Orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome, Rome, Italy

². Department of Biology and Biotechnologies “Charles Darwin”, Sapienza University of Rome, Rome, Italy

³. GSTeP Organoids Research Core Facility, Fondazione Policlinico A. Gemelli Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy

⁴. Department of Drug Chemistry and Technologies, Sapienza University of Rome, Rome, Italy

⁵. Pasteur Institute, Cenci-Bolognetti Foundation, Sapienza University of Rome, Rome, Italy

⁶. Department of BioSciences, University of Milan, Milan, Italy

⁷. Multidisciplinary Breast Center, Dipartimento Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, Catholic University of the Sacred Heart, Rome, Italy

⁸. Department of Neuroscience, Section of Human Anatomy, Catholic University of the Sacred Heart, Rome, Italy

⁹. Oncogenomic and Epigenetic Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy

francesco.fazi@uniorma1.it

alessandro.fatica@uniroma1.it

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Bianca Cesaro, Alessia Iaiza, Fabio Piscopo, Marco Tarullo, Eleonora Cesari, Dante Rotili, Antonello Mai, Alberto Diana, Michela Londero, Luca Del Giacco, Riccardo Masetti, Alba Di Leone, Chiara Naro, Silvia Masciarelli, Giulia Fontemaggi, Claudio Sette, Francesco Fazi, Alessandro Fatica. Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3. Cancer Communications, 2024, 44(2): 282-286 DOI:10.1002/cac2.12509

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