Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

Okan Safak; Shenghan Wang; Carmen Mota Reyes; Ibrahim Halil Gürcinar; Sergey Tokalov; Nedim Can Cevik; Kivanc Görgülü; Bengi Su Yilmaz; Emre Erdogan; Linhan Ye; Qiaolin Li; Elif Arik Sever; Samed Özer; Güldal Süyen; Helmut Friess; Güralp Onur Ceyhan; Rouzanna Istvanffy; Hana Algül; Ihsan Ekin Demir

doi:10.1002/cac2.12496

Cancer Communications ›› 2024, Vol. 44 ›› Issue (1) :178 -182. DOI: 10.1002/cac2.12496

LETTER TO THE EDITOR

Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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¹. Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Bavaria, Germany

². Department of General Surgery, HPB-Unit, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Istanbul, Turkey

³. Comprehensive Cancer Center München, Klinikum rechts der Isar, Technical University of Munich, School of Medicine, Munich, Bavaria, Germany

⁴. Department of Hematology, Oncology and Tumor Immunology, Charité University Medicine Berlin, Campus Virchow Clinic, Berlin, Berlin, Germany

⁵. Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul, Istanbul, Turkey

⁶. Department of Physiology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Istanbul, Turkey

⁷. Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery, Munich, Germany

⁸. Neural Influences in Cancer (NIC) International Research Consortium, Munich, Germany

ekin.demir@tum.de

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Okan Safak, Shenghan Wang, Carmen Mota Reyes, Ibrahim Halil Gürcinar, Sergey Tokalov, Nedim Can Cevik, Kivanc Görgülü, Bengi Su Yilmaz, Emre Erdogan, Linhan Ye, Qiaolin Li, Elif Arik Sever, Samed Özer, Güldal Süyen, Helmut Friess, Güralp Onur Ceyhan, Rouzanna Istvanffy, Hana Algül, Ihsan Ekin Demir. Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy. Cancer Communications, 2024, 44(1): 178-182 DOI:10.1002/cac2.12496

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References

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[1]	GuoF, WangY, LiuJ, MokSC, XueF, ZhangW. CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks. Oncogene. 2016;35(7):816-826.

[2]	Mundy-BosseBL, YoungGS, BauerT, Binkley E, BloomstonM, BillMA, et al. Distinct myeloid suppressor cell subsets correlate with plasma IL-6 and IL-10 and reduced interferon-alpha signaling in CD4(+) T cells from patients with GI malignancy. Cancer Immunol Immunother. 2011;60(9):1269-1279.

[3]	KalluriR. The biology and function of fibroblasts in cancer. Nat Rev Cancer. 2016;16(9):582-598.

[4]	DemirIE, Kujundzic K, PfitzingerPL, SaricaogluOC, TellerS, KehlT, et al. Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells. Proc Natl Acad Sci U S A. 2017;114(1):E85-E94.

[5]	DemirIE, Tieftrunk E, SchornS, SaricaogluOC, Pfitzinger PL, TellerS, et al. Activated Schwann cells in pancreatic cancer are linked to analgesia via suppression of spinal astroglia and microglia. Gut. 2016;65(6):1001-1014.